软脉煎联合辛伐他汀、阿司匹林对肾精亏虚型颈动脉粥样硬化患者baPWV、ABI的影响  

The Influence of Decoction for Softening Meridians in Combination with Simvastatin and Bayaspirin Tablets on Brachial-ankle Pulse Wave Conduction Velocity and Ankle-brachial Indexes

作　　者：孙国珺[1] 王臻楠[1] 顾耘[1] 杜文婷[1] SUN Guo-jun;WANG Zhen-nan;GU Yun;DU Wen-ting(Longhua Hospital Affiliated to Shanghai University of TCM,Shanghai,China,200030)

机构地区：[1]上海中医药大学附属龙华医院,上海200030

出　　处：《河南中医》2018年第11期1673-1677,共5页Henan Traditional Chinese Medicine

基　　金：上海市卫生和计划生育委员会项目(编号:2014LP089A)

摘　　要：目的:观察软脉煎联合辛伐他汀和阿司匹林对肾精亏虚型颈动脉粥样硬化患者肱踝脉搏波传导速度(pulse wave velocity,ba PWV)及踝臂指数(ankle-braehial index,ABI)的影响,探讨中药软脉煎对动脉血管弹性和僵硬度的作用。方法:将98例肾精亏虚型颈动脉粥样硬化患者随机分为对照组和治疗组各49例。对照组予辛伐他汀和阿司匹林治疗,治疗组在对照组用药的基础上加用中药软脉煎治疗,两组疗程均为6个月。治疗前、治疗3个月、6个月后分别比较两组患者的肾精亏虚程度积分,监测两组患者治疗前后ba PVW、ABI变化情况。结果:组内比较,治疗3个月、6个月后,治疗组肾精亏虚程度积分较治疗前降低(P <0. 01),对照组肾精亏虚程度积分较治疗前升高(P <0. 05);组间比较,治疗3个月、6个月后,治疗组肾精亏虚程度积分较对照组低(P <0. 05)。治疗组治疗后ba PWV与治疗前比较,差异无统计学意义(P <0. 05),对照组治疗后ba PWV较治疗前升高(P <0. 01),两组间ba PWV差值比较,治疗组较对照组更大(P <0. 01)。两组治疗后ABI与本组治疗前比较,差异均无统计学意义(P> 0. 05);两组间ABI的差值(治疗前-治疗后)比较,差异无统计学意义(P> 0. 05)。结论:软脉煎联合辛伐他汀和阿司匹林治疗可以延缓ba PWV的上升,通过改善动脉弹性和僵硬度来延缓动脉硬化发展。Objective: To observe the influence of Decoction for Softening Meridians in combination with simvastatin and Bayaspirin Tablets on brachial-ankle pulse wave conduction velocity and ankle-brachial indexes,and investigate the effect of Chinese herbal compound Decoction for Softening Meridians on arterial elasticity and stiffness. Methods: Ninety-eight cases of carotid atherosclerosis with deficiency of kidney essence were randomly divided into the control group and the treatment group,with 49 cases in each group. The ones in the control group were treated with simvastatin and Bayaspirin Tablets,while the ones in the treatment group were treated with Decoction for Softening Meridians on the basis of the control group. The course of treatment lasted for 6 months. Before the treatment,3 months and 6 months after the treatment,the scores of kidney essence deficiency were recorded, and the brachial-ankle pulse wave velocity ( baPWV) and ankle-brachial indexes ( ABI) were monitored before and after the treatment. Ankle brachial indexes were used to analyze the effect of Decoction for Softening Meridians. Results: There was no significant difference in baPWV in the treatment group between and after the treatment. BaPWV in the control group was higher than that before the treatment ( P < 0. 01) . The difference of baPWV in the treatment group before and after the treatment was more significant than that of the control group ( P < 0. 01) . Conclusion: Decoction for Softening Meridians in combination with simvastatin and Bayaspirin Tablets can delay the rise of baPWV and delay the development of arteriosclerosis by improving arterial elasticity and stiffness.

关 键 词：颈动脉粥样硬化 肾精亏虚证 软脉煎 辛伐他汀 肱踝脉搏波传导速度 踝臂指数 

分 类 号：R259.435[医药卫生—中西医结合]