阿奇霉素序贯疗法对肺炎支原体感染儿童伴慢性咳嗽的临床疗效评价  

Evaluation on Clinical Efficacy of Sequential Therapy of Azithromycin in Mycoplasma Pneumonia Infection Patients with Chronic Cough

作　　者：郑少娟[1] 陈巧彬[1] 林志[1] 林新富[1] ZHENG Shao-juan;CHEN Qiao-bin;LIN Zhi;LIN Xin-fu(Depart.of Pediatrics,Provincial Clinical Medical School Affiliated to Fujian Medical University,Fuzhou 350001,China)

机构地区：[1]福建医科大学附属省立临床医学院儿科,福州350001

出　　处：《抗感染药学》2018年第10期1760-1762,1805,共4页Anti-infection Pharmacy

摘　　要：目的:评价阿奇霉素序贯疗法对肺炎支原体(Mycoplasma Pneumonia, MP)感染儿童伴慢性咳嗽(chronic cough,CC)的疗效,分析MP感染与儿童慢性咳嗽的相关性。方法:选取2016年3月—2018年3月间收治的诊断为慢性咳嗽患儿106例资料作为观察组,并以同期收治的急性支气管炎患儿106例资料作为对照组;统计两组患者资料中血清肺炎支原体抗体(MP-IgM)的检测结果,比较MP-IgM阳性率的差异;并将观察组MP-IgM阳性患儿随机分为A组和B组,A组患者给予口服阿奇霉素和常规治疗,B组患者给予常规治疗;比较两组患儿治疗后的总有效率及治疗期间不良反应的发生率差异,以及治疗后临床症状(体温、咳嗽、肺部啰音)复常时间差异。结果:观察组患儿56例MP-IgM呈阳性(占52.83%),对照组患儿9例呈阳性(占8.49%),两组患儿MP感染率经组间比较其差异有统计学意义(χ2=49.01,P<0.05);此外,A组患儿治疗后的治愈率为60.71%和总有效率为96.43%分别优于B组为17.86%和77.78%(χ2=10.781,χ2=5.250,P<0.05);A组患儿治疗后临床症状(体温、咳嗽、肺部啰音)复常时间均明显早于B组(P<0.05)。结论:慢性咳嗽患儿MP感染率高于急性支气管炎患儿,采用口服阿奇霉素治疗对MP感染伴慢性咳嗽患儿的疗效较为显著,且安全性高,有效改善了患儿临床症状。Objective: To evaluate the clinical efficacy of sequential therapy of azithromycin in mycoplasma pneu-monia infection patients with chronic cough, and to analyze the correlation between mp infection and chronic cough inchildren. Methods :Data of 106 cases of children diagnosed with chronic cough admitted between March 2016 andMarch 2018 were selected as the observation group, and 106 cases of children with acute bronchitis admitted during thesame period were used as the control group. Results: In the observation group, 56 cases of mp-igm were positive(52.83%), while in the control group, 9 cases were positive (8.49%).The difference of MP infection rate between thetwo groups was statistically significant (χ 2 =49.01, P<0.05). In addition, the cure rate and total effective rate of the chil-dren in group A were 60.71% and 96.43%, respectively higher than those in group B (17.86% and 77.78%). The recov-ery time of clinical symptoms (temperature, cough,and lung volumus) of the children in group A was significantly earli-er than that in group B (P<0.05). Conclusion: MP infection rate was higher in children with chronic cough than in chil-dren with acute bronchitis. The efficacy of oral azithromycin in the treatment of MP infection with chronic cough wassignificant and the safety was high, effectively improving the clinical symptoms of the children.

关 键 词：慢性咳嗽 肺炎支原体 阿奇霉素 临床疗效 肺炎支原体抗体(MP-IgM) 

分 类 号：R969.3[医药卫生—药理学]