住院患者梅毒抗体检测结果分析  

Analysis of Syphilis Infection in General Hospital Among Inpatients

作　　者：白园园 陈占国[1] 王慧燕[1] 郑晓群[1] Bai Yuanyuan;Chen Zhanguo;Wang Huiyan(Department of Laboratory Medicine,The Second Affiliated Hospital of Wenzhou Medical University,Zhejiang 325000,China)

机构地区：[1]温州医科大学附属第二医院检验医学学科,325000

出　　处：《医学研究杂志》2018年第11期159-163,共5页Journal of Medical Research

摘　　要：目的深入分析笔者医院住院患者中的梅毒抗体检测结果,为梅毒的防治工作提供依据。方法采用TP-ELISA法对49773例住院患者进行初筛,阳性标本再用TPPA法进行确认试验,用TRUST检测其效价,对TP-ELISA法结果分组进一步分析假阳性的来源和患者疾病谱,并分析梅毒抗体阳性患者的年龄、性别和科室分布特点。结果梅毒抗体总阳性率为1. 87%,TRUST阳性150例,TP-ELISA法假阳性50例,TP-ELISA法的1 <S/CO值<4组假阳性率高于S/CO值≥4组(P <0. 01),假阳性患者疾病谱主要以脑梗死、冠心病、高血压等老年人多发病为主;随着年龄增加,阳性率呈上升趋势,男女性阳性率比较差异无统计学意义(P> 0. 05);梅毒抗体阳性率排前5位的科室分别为肿瘤放化疗科、神经内科、呼吸内科、肾内科及消化内科。结论在梅毒抗体的检测中,TP-ELISA虽可用于大批量筛查,但由于其局限性需联合TPPA法检测,梅毒抗体阳性率随年龄递增。笔者医院梅毒抗体阳性患者分布于各临床科室,应全面加强对重点科室、重点人群特别是老年住院患者的梅毒筛查和确诊工作。Objective To analyze the results of syphilis in the general hospital and provide reference for the prevention and treatment of syphilis.Methods Totally 49773 clinical specimens from common inpatients were underwent TP -ELISA method.All screening positive samples were further tested by TPPA method.TRUST method was used to detect the titer.The results of TP -ELISA method were used to further analyze the source of false positive and the disease spectrum of patients,and to elucidate the age,sex and the distribution characteristics of the patients with syphilis antibody.Results The positive rate was 1.87%.There were 150 positive eases tested by TRUST.There were 50 false positive eases.The false positive of S/CO (≥4)was significantly higher than the other group (P <0.01).There was little difference between male and females (P >0.05).The positive rate increases with age.The higher positive rate occurred in the department of oncology,neurology,respiratory,nephrology and gastrology.Conclusion In the detection of syphilis antibody, TP -ELISA method can be used for mass screening,but it should be combined with the TPPA method.The patients with syphilis antibody are distributed in various clinical departments,so it is necessary to strengthen the screening and diagnosis of syphilis in the key departments,especially in elderly inpatients.

关 键 词：梅毒抗体 酶联免疫吸附试验 假阳性 住院患者 

分 类 号：R1[医药卫生—公共卫生与预防医学]