2型糖尿病患者下肢动脉彩超异常与血细胞比值的相关性研究  

Association between blood cell ratios and lower extremity arterial ultrasonography abnormalities in patients with type 2diabetes mellitus

作　　者：李玉红[1] 陈雨[1] 范振迁[1] 郭剑超[1] Li Yuhong;Chen Yu;Fan Zhenqian;Guo Jianchao(Department of Endocrinology,the Second Hospital of Tianjin Medical University,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院内分泌科,300211

出　　处：《中华全科医师杂志》2018年第12期1009-1012,共4页Chinese Journal of General Practitioners

摘　　要：回顾性分析2014年10月至2017年6月在我院诊治的380例2型糖尿病患者的临床资料,依双下肢动脉彩超检查结果分3组:103例无病变者为A组、132例轻度病变者为B组、145例中重度病变者为C组,选取年龄、性别相匹配的健康体检者100例为正常对照(对照组),均取静脉血检测中性粒细胞/淋巴细胞值(NLR)、血小板/淋巴细胞值(PLR)及各项生化指标。A、B、C组NLR分别为1.91±0.43、2.23±0.36和2.71±0.48,PLR分别为101.4±43.2、109.7±38.1和130.2±46.2,均高于对照组的1.73±0.41和94.8±32.9(均P<0.05),B组、C组高于A组(P<0.05),差异具有统计学意义。logistic回归分析显示,NLR、PLR、超敏CRP、糖化血红蛋白(HbA1c)、LDL-C与2型糖尿病下肢动脉病变显著正相关,OR值(95%CI)分别为2.26(1.25~4.09)、1.97(1.15~3.56)、2.31(1.35~4.33)、2.38(1.41~4.49)和2.01(1.22~3.43),均P<0.01;建立多个模型校正年龄、性别、BMI、病程、血压、血脂、血糖、血肌酐、血尿酸、24h尿微量白蛋白定量后,NLR(OR=2.01,95%CI1.15~3.63,P<0.05)、PLR(OR=1.75,95%CI1.04~3.28,P<0.05)与2型糖尿病下肢动脉病变相关。Clinical data of 380 patients with type 2 diabetes mellitus (T2DM) admitted in theSecond Hospital of Tianjin Medical University from October 2014 to June 2017 were retrospectivelyreviewed. Patients were divided into 3 groups according to the results of lower extremity arterialultrasonography: 103 patients without lower extremity arterial disease (group A), 132 patients with mildarterial disease (group B), 145 patients with moderate to severe lower extremity arterial disease (group C);and 100 healthy subjects served as control group. Blood routine parameters and blood biochemistry weremeasured; the results showed that blood cell ratios in T2DM patients were significantly higher than those incontrol group (P<0.05), and blood cell ratios in group B and group C were higher than those in group A(P<0.05). Pearson correlation analyses indicated that neutrophil/lymphocyte ratio (NLR), platelet/lymphocyteratio (PLR), hs-CRP, HbA1c, LDL-C were significantly associated with lower extremity arterial disease in T2DM patients. Logistic analysis showed that NLR(OR=2.01,95%CI: 1.15-3.63,P<0.05)and PLR(OR=1.75,95%CI: 1.04-3.28,P<0.05)were risk factors for lower extremity arterial disease in patients with type2 diabetes mellitus.

关 键 词：糖尿病 2型 外周血管疾病 下肢 血细胞计数 

分 类 号：R587.2[医药卫生—内分泌]