奥瑞凝胶对反流性食管炎患者血清胃泌素水平的影响  

Effects of Orient Gel on Serum Gastrin Level in Patients with Reflux Esophagitis

作　　者：魏群[1] 魏晏[2] 魏明[3] 宋大龙 郜新莲[1] WEI Qun;WEI Yan;WEI Ming;SONG Dalong;GAO Xinlian(Henan University of Chinese Medicine,Zhengzhou Henan China 450046;The Third Affiliated Hospital to Henan University of Chinese Medicine,Zhengzhou Henan China 450008;The First Affiliated Hospital to Henan University of Chinese Medicine,Zhengzhou Henan China 450000)

机构地区：[1]河南中医药大学,河南郑州450046 [2]河南中医药大学第三附属医院,河南郑州450008 [3]河南中医药大学第一附属医院,河南郑州450000

出　　处：《中医学报》2018年第11期2218-2221,共4页Acta Chinese Medicine

基　　金：河南省社会发展领域科技攻关项目(142102310133)

摘　　要：目的:观察奥瑞凝胶对反流性食管炎患者血清胃泌素水平的影响。方法:60例反流性食管炎患者按照随机数表法将患者平均分为对照组和观察组。对照组患者给予常规治疗方法,观察组患者在对照组治疗基础上给予奥瑞凝胶。比较两组患者中医证候积分、临床疗效、胃镜疗效及胃泌素水平。结果:观察组胃镜疗效的痊愈率为43. 33%、显效率为40. 00%,均显著高于对照组的13. 33%、26. 67%;观察组胃镜疗效有效率为96. 67%,显著高于对照组的73. 33%,差异均有统计学意义(P <0. 05)。治疗后观察组患者中医证候积分:胸胁胀满(1. 35±0. 62)分、吞酸烧心(1. 05±0. 36)分、呃逆嗳气(1. 13±0. 64)分、情志抑郁(1. 25±0. 38)分等均显著低于对照组患者胸胁胀满[(3. 87±0. 63)分]、吞酸烧心[(3. 67±1. 13)分]、呃逆嗳气[(3. 18±0. 72)分]、情志抑郁[(2. 94±0. 55)分]的中医证候积分,差异均有统计学意义(P <0. 05)。观察组综合临床疗效的显效率为(50. 00%)显著高于对照组(30. 00%),无效率(6. 67%)显著低于对照组(33. 33%);观察组临床疗效有效率为(93. 33%)显著高于对照组(66. 67%),差异有统计学意义(P <0. 05)。两组患者治疗前血清胃泌素水平比较,差异无统计学意义(P> 0. 05);治疗后观察组患者血清胃泌素水平为(181. 03±21. 44)ng·L-1显著高于对照组患者的(114. 37±19. 85) ng·L-1,差异有统计学意义(P <0. 05)。结论:奥瑞凝胶治疗反流性食管炎患者临床疗效显著,可显著降低患者中医证候积分,提高胃泌素水平。Objective: To observe the effects of orient gel on serum gastrin level in patients with reflux esophagitis. Methods: 60 patients with reflux esophagitis were randomly divided into control group and observation group according to random number table method. The patients in the control group were given conventional treatment,and the patients in the observation group were given Ori gel on the basis of the treatment of the control group. TCM syndrome scores,clinical efficacy,gastroscopic efficacy and gastrin levels were compared between the two groups. Results: The cure rate of the gastroscope in the observation group was 43. 33%,and the effective rate was 40. 00%,which was significantly higher than 13. 33% and 26. 67% of the control group. The effective rate of gastroscopy in the observation group was 96. 67%,which was significantly higher than that in the control group ( 73. 33%) . The difference was statistically significant ( P < 0. 05) . After treatment,the TCM syndrome scores: thoracic fullness ( 1. 35 ± 0. 62) , swallowing acid heartburn ( 1. 05 ± 0. 36) , sputum sputum ( 1. 13 ± 0. 64) , emotional depression ( 1. 25 ± 0. 38) of the observation group were significantly lower than the TCM syndrome scores ( 3. 87 ± 0. 63) , swallowing heartburn ( 3. 67 ± 1. 13) ,hiccups ( 3. 18 ± 0. 72) , and emotional depression ( 2. 94 ± 0. 55) of the control group. The effective rate of comprehensive clinical efficacy of the observation group was ( 50. 00%) significantly higher than that of the control group ( 30. 00%) ,and the inefficiency ( 6. 67%) was significantly lower than that of the control group ( 33. 33%) . The effective rate of clinical observation in the observation group ( 93. 33%) was significantly higher than that in the control group ( 66. 67%) , and the difference was statistically significant ( P < 0. 05) . There was no significant difference in serum gastrin levels between the two groups before treatment ( P > 0. 05) . After treatment,the serum gastrin level of the observation group was ( 181. 03 ±

关 键 词：反流性食管炎 奥瑞凝胶 胃泌素 奥美唑拉肠溶胶囊 中西医结合 

分 类 号：R259.71[医药卫生—中西医结合]