血府逐瘀汤治疗血液透析患者不宁腿综合征疗效观察  

Curative Effect Observation on Xuefu Zhuyu Tang for Patients Undergoing Hemodialysis with Restless Legs Syndrome

作　　者：刘张红[1] 吴芊葭[1] 黄蔚霞[1] LIU Zhanghong;WU Qianjia;HUANG Weixia

机构地区：[1]温州市中医院肾脏科,浙江温州325000

出　　处：《新中医》2018年第12期110-112,共3页New Chinese Medicine

摘　　要：目的:观察血府逐瘀汤治疗血液透析患者不宁腿综合征(RLS)临床疗效。方法:将维持性血液透析伴RLS患者40例随机分为2组,2组均给予常规血液透析治疗及对症处理,观察组给予血府逐瘀汤,对照组给予口服加巴喷丁。治疗8周,治疗前后使用RLS评分量表(IRLS)评价,检测患者治疗前后白蛋白、血肌酐、尿素氮、血尿酸、碱性磷酸酶、血红蛋白、转铁蛋白饱和度、钾、钙、磷、全段甲状旁腺激素等指标。结果:治疗后,2组血红蛋白较治疗前升高(P <0.01),但2组间比较,差异无统计学意义(P> 0.05)。观察组血白蛋白在治疗后较治疗前改善(P <0.05),但治疗后2组间血白蛋白比较,差异无统计学意义(P> 0.05)。治疗后,观察组血钾较治疗前升高(P <0.05),但2组间治疗后血钾比较,差异无统计学意义(P> 0.05)。治疗后,2组患者的RLS评分明显下降(P <0.01),但2组之间比较,差异无统计学意义(P> 0.05)。说明血府逐瘀汤能改善患者RLS临床症状,效果等同于加巴喷丁。结论:血府逐瘀汤化裁治疗能缓解患者症状,疗效与加巴喷丁相当。Objective:To observe the clinical effect of Xuefu Zhuyu tang for patients undergoing hemodialysis with restless legs syndrome(RLS). Methods:Divided 40 cases of patients undergoing persistent hemodialysis with RLS into two groups randomly. The two groups received routine treatment of hemodialysis and symptomatic treatment. The observation group additionally received Xuefu Zhuyu tang for treatment,while the control group additionally received oral administration of gabapentin. The treatment lasted for eight weeks. Evaluated the patients with international restless legs scale (IRLS) and detected the indexes of albumin,serum creatinine,urea nitrogen, serum uric acid, alkaline phosphatase, hemoglobin, transferrin saturation, potassium, calcium, phosphorus and intact parathyroid hormone of patients before and after treatment. Results:After treatment,the levels of hemoglobin in the two groups were improved when compared with those before treatment (P<0.01), but no significant difference was found in the comparison of hemoglobin between the two groups (P>0.05). The level of serum albumin in the observation group was improved when compared with that before treatment(P<0.05),but no significant difference was found in the comparison of serum albumin between the two groups(P > 0.05). After treatment,the level of serum potassium in the observation group was increased when compared with that before treatment (P < 0.05), but no significant difference was found in the comparison of serum potassium between the two groups (P>0.05). After treatment,RLS scores in the two groups were significantly decreased when compared with those before treatment (P<0.01),but no significant difference was found in the comparison of RLS scores between the two groups (P>0.05). The above results proved that Xuefu Zhuyu tang can improve the clinical symptoms of patients and its curative effect is equivalent to that of gabapentin. Conclusion: The therapy of modified Xuefu Zhuyu tang can relieve the symptoms of patients, whose curative effect is equivale

关 键 词：不宁腿综合征(RLS) 血府逐瘀汤 加巴喷丁 血液透析 

分 类 号：R459.5[医药卫生—治疗学] R597[医药卫生—临床医学]