葛根素注射液联合巴曲酶治疗突发性耳聋的临床疗效观察  

Clinical observation of batroxobin combined with puerarin Injection in the treatment of sudden deafness

作　　者：王翠 WANG Cui(Ear and Throat Department, Yulin Xingyuan Hospital, Yulin 719000, China)

机构地区：[1]榆林市星元医院眼耳鼻喉科,陕西榆林719000

出　　处：《药物评价研究》2018年第11期2061-2064,共4页Drug Evaluation Research

摘　　要：目的研究葛根素注射液联合巴曲酶治疗突发性耳聋的临床效果。方法选择2016年2月—2016年12月在榆林市星元医院进行诊治的突发性耳聋患者78例,随机分为两组,每组各39例。对照组给予巴曲酶注射液,每次10 BU,加入500 mL生理盐水中稀释后进行静脉滴注,每两天1次。观察组在对照组基础上联合静脉滴注葛根素注射液治疗,将0.4 g葛根素注射液加入250 mL生理盐水中进行静脉滴注,每天1次。两组均治疗10 d。比较两组的临床治疗效果,以及治疗前后的活化部分凝血活酶时间、凝血酶时间、凝血酶原时间和血浆纤维蛋白原,全血黏度低切、血细胞比容、全血黏度高切、血浆黏度和纯音听阈值。结果观察组的有效率为89.74%,明显高于对照组的71.79%,差异有统计学意义(P<0.05)。两组治疗后的凝血酶时间、活化部分凝血活酶时间以及凝血酶原时间均明显升高,血浆纤维蛋白原明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且两组间相比差异有统计学意义(P<0.05)。两组治疗后的全血黏度低切、血细胞比容、全血黏度高切及血浆黏度均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组明显低于对照组,差异有统计学意义(P<0.05)。两组治疗后的纯音听阈值均明显改善,同组治疗前后比较差异有统计学意义(P<0.05);且观察组明显优于对照组,差异有统计学意义(P<0.05)。结论葛根素注射液联合巴曲酶治疗突发性耳聋的临床效果明显优于单独使用巴曲酶,不仅可以有效改善患者的临床症状还可以改善血液流变学状态以及血液高凝状态。Objective To investigate the clinical effect of batroxobin combined with Puerarin Injection in the treatment of sudden deafness. Methods Selected 78 cases of patients with sudden deafness who were treated in our hospital from January 2016 to December 2016, divided into two groups randomly. The clinical therapeutic effect of two groups, and the activated partial thromboplastin time and thrombin time, prothrombin time and fibrinogen, whole blood viscosity at low shear rate, hematocrit, whole blood viscosity at high shear rate, plasma viscosity and pure tone threshold were compared before and after treatment.Results After treatment, the effective rate of the observation group was 89.74%(35/39), significantly higher than that of the control group 71.79%(28/39)(P < 0.05); thrombin time, activated partial thromboplastin time and prothrombin time of the two groups were increased significantly(P < 0.05), plasma fibrinogen decreased significantly(P < 0.05), and compared between the two groups has significant difference(P < 0.05); the low shear whole blood viscosity, hematocrit, whole blood viscosity at high shear rate and plasma viscosity of the two groups were significantly decreased(P < 0.05), and the observation group decreased more obviously(P < 0.05); the value of pure tone audiometry of the two groups were significantly improved(P < 0.05), and the observation group is more obvious(P <0.05).Conclusion Batroxobin combined with puerarininjection in the treatment of sudden deafness was significantly better than the single use of batroxobin, not only can effectively improve the clinical symptoms of the patients can also improve blood rheology and blood hypercoagulability.

关 键 词：巴曲酶 葛根素注射液 突发性耳聋 临床效果 

分 类 号：R969[医药卫生—药理学]