乌头药对配伍研究进展  

Research progress of aconitum on drug pair compatibility

作　　者：赫宇霏 慈小燕[2,3] 伊秀林[2,3] 曾勇[2,3] 刘昌孝 李亚卓[2,3] HE Yufei;CI Xiaoyan;YI Xiulin;ZENG Yong;LIU Changxiao;LI Yazhuo(Shenyang Pharmaceutical University, Shenyang 110016, China;Tianjin Institute of Pharmaceutical Research, State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin 300301, China;Tianjin Institute of Pharmaceutical Research, Tianjing 300193, China)

机构地区：[1]沈阳药科大学,辽宁沈阳110016 [2]天津药物研究院新药评价有限公司,释药技术与药代国家重点实验室,天津300301 [3]天津药物研究院,天津300193

出　　处：《药物评价研究》2018年第11期2123-2128,共6页Drug Evaluation Research

基　　金：国家重点研发计划(2016YFE0121400);国家自然科学基金重点项目(81430096)

摘　　要：乌头汤始记于《金匾要略》,是东汉时代著名医学家张仲景创制的一首名方,具有温经祛寒、除湿止痛的功效,主治寒湿痹证。乌头汤是由乌头、甘草、白芍、黄芪和麻黄5味药组成,其中乌头既是乌头汤的君药,又是具有毒性成分的药材,所以常配伍给药以达到促进乌头疗效和制约乌头毒性的目的,除乌头汤全方组外,临床也常采用全方加减味或药对用于治疗。对近年来乌头配伍药材甘草、白芍、黄芪、麻黄及其活性成分对外排转运体和细胞色素P450影响的文献进行回顾,总结整理了与乌头伍用药材与其活性成分对外排转运体和细胞色素的作用,以期通过分析药材活性成分对外排转运体和细胞色素P450的调控及作用,来诠释乌头伍用药材的减毒增效机制,解析复方配伍规律的科学性。为乌头配伍合理应用和临床药理研究提供了基础,并对临床上安全、有效用药具有重要的意义。Wutou Decoction recorded in Golden Chamber Guidance and Strategy is a famous prescription created by famous doctor named Zhang Zhongjing in Dong Han age. This prescription have the efficacy of warm venation so that dispel cold, drive away damp and alleviate pain, it can mainly treat arthralgia sydromes caused by cold and damp. Wutou Decoction is composed of Radix Aconiti Praeparat, Radix glycyrrhizae, Radix paeoniae alba, Radix Astragali, Radix Ephedrae. Radix Aconiti Praeparat is not only sovereign herb, but also the toxic herb. Thus, it is always administrated with other herb in order to reduce the toxicity and improve the pharmaceutical efficacy. Besides the decoction group, the modified group and drug pair are also utilized in the clinical treatment.According to recent article about the effect of Radix glycyrrhizae, Radix Paeoniae alba, Radix Astragali, Radix Ephedrae in Wutou decoction and their activity components impact on the efflux transporter and cytochrome P450. Summarizing the results of effectiveness, and exploring the opinion of further research. Hoping interpreting the mechanism of attenuating toxi and fortifying consequence, explaining the scientificity of compound compatibility though the effect of the efflux transporter and cytochrome P450. Those provide a basis for the rational application of Wutou compatibility and clinical pharmacological research and are great significance for clinical safety and effective drug use.

关 键 词：乌头 配伍 外排转运体 药物代谢酶 

分 类 号：R282[医药卫生—中药学]