西宁地区慢性阻塞性肺疾病急性加重期患者红细胞的血液流变学和红细胞变形性的研究  

The Study on Hemorheological Parameters and Erythrocyte Deformability in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Xining

作　　者：李满桂[1] 李生梅[1] 刘成花 解承娟 马慧英[1] 马秀清[1] Li Mangui;Li Shengmei;Liu Chenghua;Xie Chengjuan;Ma Huiying;Ma Xiuqing(The Red Cross Hospital of Qinghai (810000))

机构地区：[1]青海红十字医院,810000

出　　处：《青海医药杂志》2018年第8期1-3,共3页Qinghai Medical Journal

摘　　要：目的:探讨西宁地区慢性阻塞性肺疾病(COPD)急性加重期患者血液流变学参数和红细胞变形性的研究。方法:分别测定168例COPD急性发作期患者(研究组)和170例正常人(对照组)的血液流变学参数和红细胞聚集指数、红细胞刚性指数、红细胞变形指数、棘红细胞百分比、血沉等。结果:COPD急性加重期患者血液呈高黏状态,全血和血浆黏度增加,红细胞聚集指数、红细胞刚性指数增加、红细胞变形指数减低、棘形红细胞百分比升高、血沉加快、红细胞压积增高等。结论:COPD急性加重期患者红细胞黏度增加,变形性下降,棘红细胞增多等指标均可作为评价本地区COPD患者严重程度、疗效的参考指标。Objective:This study is aimed to investigate the hemorheological parameters and erythrocyte deformability in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD)in Xining.Methods:168patients with acute attack of COPD(study group)and 170normal persons(control group)were detected respectively with their Hemorheological parameters,erythrocyte aggregation index,erythrocyte rigidity index,erythrocyte deformability index,percentage of spinous erythrocyte and erythrocyte sedimentation rate.Results:The blood of patients with acute exacerbation of COPD was in a high viscous state,in which the whole blood,plasma viscosity,erythrocyte aggregation index and erythrocyte rigidity index increased,while the erythrocyte deformability index decreased,spinous erythrocyte percentage increased,erythrocyte sedimentation rate increased,and hematocrit increased.Conclusion:The indexes of erythrocyte viscosity,deformability and acanthocytosis in patients with acute exacerbation of COPD can be used as a reference index to evaluate the severity and efficacy of patients with COPD in this area.

关 键 词：肺心病 红细胞 血液流变学 红细胞变形性 

分 类 号：R339.54[医药卫生—人体生理学] R563[医药卫生—基础医学]