肺炎支原体感染患儿视黄醇结合蛋白和T细胞亚群的变化及意义  

Effects and changes of retinol-binding protein and T cell subsets in children with mycoplasma pneumoniae infection

作　　者：梁导艳[1] 郭春艳[1] 封青[1] 黄晓燕[1] 胡军[1] LIANG Dao-yan;GUO Chun-yan;FENG Qing(Central Laboratory of Shanxi Provincial People's Hospital,Xi an 710068,China)

机构地区：[1]陕西省人民医院中心实验室,陕西西安710068

出　　处：《中国实验诊断学》2018年第12期2053-2056,共4页Chinese Journal of Laboratory Diagnosis

基　　金：陕西省人民医院孵化基金项目(2015YX-4);陕西省重点研发计划项目(2017ZDXM-NY-066);陕西省创新能力支撑计划项目(2018PT-24)

摘　　要：目的探讨支原体肺炎感染患儿后视黄醇结合蛋白(RBP)、T细胞亚群水平的变化,研究视黄醇结合蛋白和T细胞亚群检测对支原体肺炎感染的临床指导作用及价值。方法选取65例支原体肺炎患儿为观察组,40例健康儿童为对照组,收集两组血清及全血。观察组病例均符合儿童肺炎诊断标准。两组均检测血清RBP含量和全血淋巴细胞表面CD3+、CD3+CD4+、CD3+CD8+百分比及CD4/CD8值。结果观察组总CD3+、CD3+CD4+细胞百分比、CD4/CD8比值显著低于对照组(P<0.01);观察组CD3+CD8+百分比显著高于对照组(P<0.01)有统计学意义;观察组RBP显著低于对照组(P<0.05)。结论 RBP和T细胞亚群在儿童感染支原体肺炎时能敏感的反映肝功能及免疫功能的变化,对临床后续治疗有较高的指导意义及价值。Objective To investigate the changes of retinol.binding protein (RBP)and T cell subsets in children with mycoplasmal pneumonia infection,and provide guidance for clinical diagnosis.Methods Sixty-five children with mycoplasmal pneumonia were selected as the observation group,and forty healthy children were selected as the control group.The serum and whole blood of the two groups were collected.All cases met the diagnostic criteria for childhood pneumonia.Serum RBP levels and CD^3+,CD^3+CD^4+,CD^3+CD^8+ percentage and CD4/CD8 values were measured in both groups.Results The percentage of total CD^3+,CD^3+CD^4+ cells and CD4/CD8 ratio in the observation group were significantly lower than those in the control group (P<0.01),which was statistically significant.The percentage of CD^3+CD^8+in the observation group was significantly higher than that in the control group (P<0.01),which was statistically significant.The RBP of the observation group was significantly lower than that of the control group (P< 0.05),which was statistically significant.Conclusion RBP and T cell subsets can respond to the changes of liver func- tion and immune function in children with mycoplasmal pneumonia,which has high guiding significance and value for clinical follow-up treatment.

关 键 词：肺炎支原体 视黄醇结合蛋白 T细胞亚群 

分 类 号：R446.1[医药卫生—诊断学]