急性冠脉综合征患者血清Cysc、NT-proBNP水平变化及意义  

Changes and significance of serum Cysc and NT-proBNP level in patients with acute coronary syndrome

作　　者：师彦虎 张斌[1] 孙敏[1] 王音[1] SHI Yan-hu;ZHANG Bin;SUN Min(Internal Medicine-Cardiovascular Department,Shanxi Baoji Hospital of traditional Chinese Medicine ,Baoji 721000,China)

机构地区：[1]陕西省宝鸡市中医医院心内科,陕西宝鸡721000

出　　处：《中国实验诊断学》2018年第12期2063-2066,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨急性冠脉综合征(ACS)患者血清胱抑素C(Cysc)、N末端脑钠肽前体(NT-proBNP)水平变化及意义。方法以70例ACS患者和35例健康体检者为观察对象,对比其中35例急性心肌梗死患者(AMI组)、35例不稳定心绞痛患者(UAP组)以及35例健康组患者血清Cysc、NT-proBNP水平差异,对比不同病变程度及不同预后ACS患者Cysc、NT-proBNP水平及Gensini评分差异,分析ACS患者Cysc、NT-proBNP水平与Gensini评分的相关性。结果 AMI组和UAP组患者血清Cysc、NT-proBNP水平较健康组均显著升高,且AMI组患者血清Cysc、NTproBNP水平及Gensini评分又明显高于UAP组(P<0.05)。随着病变冠脉支数增加,患者血清Cysc、NT-proBNP水平及Gensini评分也显著升高(P<0.05)。1年内发生MACE患者血清Cysc、NT-proBNP水平及Gensini评分均明显高于未发生MACE患者(P<0.05)。ACS患者血清Cysc、NT-proBNP水平与Gensini评分均呈显著正相关(P<0.05)。结论血清Cysc、NT-proBNP水平与ACS患者病变程度及预后密切相关,为临床上诊断ACS患者病情和评估预后提供参考价值。Objective To investigate the changes and and significance of serum cystatin C (Cysc)and N-terminal pro-brain natriuretic peptide (NT-proBNP)level in patients with acute coronary syndrome (ACS).Methods 70pa- tients with ACS and 35 healthy persons were enrolled in this study.The differences of serum Cysc,NT-proBNP were compared in 35patients with acute myocardial infarction (AMI group),35 patients with unstable angina pectoris (UAP group)and 35 persons in healthy group.The differences of serum Cysc,NT-proBNP were compared in ACS patients with different disease degree and prognosis.The correlations of Cysc,NT-proBNP level and Gensini score in patients with ACS were analyzed.Results Compared with healthy group,the levels of serum Cysc,NT-proBNP in AMI group and UAP group were significantly increased,while the serum Cysc,NT-proBNP level and Gensini score in AMI group were significantly higher than UAP group (P<0.05).The serum Cysc,NT-proBNP level and Gensini score were sig- nificantly increased with number of diseased coronary arteries increased (P<0.05).The serum Cyst,NT-proBNP level and Gensini score of patients occurred MACE within 1year were significantly higher than patients not oc.curred MACE within 1year (P<0.05).The serum Cysc and NT-proBNP level had significantly positive correlations with Gensini score in patients with ACS (P<0.05).Conclusion The levels of serum Cyst and NT-proBNP are closely related to the lesion degree and prognosis of patients with ACS.

关 键 词：胱抑素C N末端脑钠肽前体 急性冠脉综合征 

分 类 号：R54[医药卫生—心血管疾病]