5-HT2a2cR交互作用与抑郁症睡眠障碍关系  

Association of 5-HT receptor gene interaction with sleep disorder among depression patients

作　　者：王琳[1] 宁南[1] 石晶[1] 杨秀贤[1] 杨艳杰[1] WANG Lin;NING Nan;SHI Jing(Department of Psychology, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province 150086, China)

机构地区：[1]哈尔滨医科大学公共卫生学院心理学教研室,黑龙江哈尔滨150086

出　　处：《中国公共卫生》2018年第12期1672-1674,共3页Chinese Journal of Public Health

基　　金：黑龙江省教育厅科学技术研究项目(12541496)

摘　　要：目的探讨五羟色胺2a、2c受体基因(5-HT2a2cR)交互作用与抑郁症睡眠障碍的关联。方法 2014年9月—2016年6月,提取黑龙江省哈尔滨市275例单相抑郁症睡眠障碍患者和300例健康对照者基因组DNA,采用单碱基延伸SNP分型技术测定5-HT2a受体的rs6315和5-HT2c受体的rs518147,检测2组基因型的多态分布;应用SPSS 18.0软件进行X2检验和二元逻辑回归分析。结果病例组携带的5-HT2a受体的rs6315基因型AA、AG、GG频率分别为74.5%(205/275)、 12.7%(35/275)和12.7%(35/275),对照组分别为83.7%(251/300)、 5.0%(15/300)、 11.3%(34/300),病例组5-HT2a受体的rs6315等位基因A、 G频率分别为80.9%(445/550)、 19.1%(105/550),对照组分别为86.2%(517/600)、13.8%(83/600),2组5-HT2a受体的rs6315基因型和等位基因频率差异均有统计学意义;5-HT2c受体的rs518147基因型和等位基因差异无统计学意义(P> 0.05);病例组与对照组5-HT2a受体的rs6315和5-HT2c受体的rs518147无交互作用,差异无统计学意义(P> 0.05)。结论 5-Ht2a受体的rs6315和5-HT2c受体的rs518147与抑郁症睡眠障碍没有明显关联。Objective To explore the association of 5-hydroxytryptamine 2A receptor(5-HT2AR)and 5-hydroxytryptamine 2C receptor(5-HT2CR)genes with sleep disorder among depression patients.Methods A total of 275 unipolar depression outpatients with sleep disorder were recruited in the Psychiatry Department of First Affiliated Hospital of Harbin Medical University and 300 gender- and age-matched healthy persons taking physical examination at the hospital and during the same period were selected between September 2014 and June 2016 in Harbin city of Heilongjiang province. The DNA of all the participants were extracted and genotype distributions of 5-HT2AR rs6315 and 5-HT2CR rs518147 genes were detected with single base extension single nucleotide polymorphism(SNP)typing technique. Chi-square test and binary logistic regression were performed with SPSS 18.0.Results The proportions of cases with 5-HT2AR rs6315 genotype of AA, AG, and GG were 74.5.0%(205/275), 12.7%(35/275), and 12.7%(35/275)and those of the controls were 83.7%(251/300), 5%(15/300), and 11.3%(34/300), respectively;the proportions of cases with 5-HT2AR rs6315 allele of A and G were 80.9%(445/550)and 19.1%(105/550)and those of the controls were 86.2%(517/600)and 13.8%(83/600). There were significant differences in the genotype and allele frequency distribution of 5-HT2AR rs6315 between the cases and the controls(P<0.05 for all);but no significant differences were observed in the genotype and allele frequency distribution of 5-HT2CR rs518147 between the cases and the controls(P>0.05 for all). There were no interactions between genes of 5-HT2AR rs6315 and 5-HT2CR rs518147 among both the cases and the controls and there was no significant difference in the interaction of the two genes between the cases and the controls(P>0.05).Conclusion 5-HT2AR rs6315 and 5-HT2CR rs518147 genes are not significantly correlated with sleep disorder among depression patients.

关 键 词：5-HT受体 基因交互作用 抑郁症睡眠障碍 

分 类 号：R181.24[医药卫生—流行病学]