静电纺定向纳米纤维及其组织工程支架应用研究进展  

Research progress for electrospun aligned nanofiber and its application in tissue engineering scaffold

作　　者：李博昱[1] 刘呈坤[1,2,3] 谭耀红 于群 孙润军[1] Li Boyu;Liu Chengkun;Tan Yaohong;Yu Qun;Sun Runjun(School of Textile and Materials,Xi'an Polytechnic University,Xi'an 710048;College of Textiles,Donghua University,Shanghai 201620;Shandong Ruyi Textile Co.,Ltd.,Jining 272073)

机构地区：[1]西安工程大学纺织与材料学院,西安710048 [2]东华大学纺织学院,上海201620 [3]山东如意科技集团有限公司,济宁272073

出　　处：《化工新型材料》2018年第12期225-228,共4页New Chemical Materials

基　　金：国家自然科学基金项目(51503168);陕西省创新人才推进计划-青年科技新星项目(2017KJXX-23);陕西省教育厅重点实验室科研计划项目(13JS035);山东省博士后创新项目专项资金资助项目(201504);西安工程大学研究生创新基金(CX201729)

摘　　要：静电纺纳米纤维以其具有模拟细胞外基质(ECM)的结构与功能,已在组织工程支架材料领域受到广泛研究。传统随机排列纳米纤维支架显示出较低的机械强力,缺少足够的生物地形指引,而定向纳米纤维的应用优势凸显。为了扩展定向纳米纤维在组织工程支架的应用,系统综述了近年来不同制备方法在构建血管、肌肉、骨和神经组织工程支架的应用进展。结果表明,三维(3D)定向纳米纤维支架具有明显的使用优势,可以结合多种电纺技术和后加工处理,以及结合其他制备组织工程支架的方法进行制备。Electrospun nanofiber has been widely used in the area of tissue engineering scaffold material due to its structure and function of emulating extracellular matrix(ECM).Traditional random nanofiber shows lower strength and lacks enough topographic cues,while aligned nanofiber can overcome the shortcomings.In order to extend the application of aligned nanofiber in the area of tissue engineering scaffold,application progress of different preparation methods in construction of blood vessel,muscle,bone and nerves tissue engineering scaffold were studied.Results showed that three dimensional(3D)aligned nanofiber scaffold had obvious advantage in using.It can be prepared through combination of many electrospinning technologies,finishing processes,and some other methods to prepare tissue engineering scaffold.

关 键 词：静电纺丝 定向纳米纤维 组织工程 支架应用 

分 类 号：TQ340.64[化学工程—化纤工业] TB383.1[一般工业技术—材料科学与工程]