巴氯芬的绿色制备工艺研究  

Green Preparation of Baclofen

作　　者：唐诗思 姚洪 艾雨晴 黄朋勉[1] TANG Shi-si;YA 0Hong;AI Yu-qing;HUANG Peng-mian(Changsha University of Science and Technology,College of Chemical and Biological Engineering,Changsha 410000,China)

机构地区：[1]长沙理工大学化学与生物工程学院,湖南长沙410000

出　　处：《精细化工中间体》2018年第5期25-28,共4页Fine Chemical Intermediates

基　　金：长沙市科技计划项目经费资助(kq1801163;kq1801052)

摘　　要：以对氯苯甲醛和丙二酸二甲酯为原料,经过Henry缩合、迈克尔加成、催化加氢以及脱羧4步反应制备得到巴氯芬,确定了催化加氢的优化条件为:以雷尼镍作为催化剂,用量为10%(m/m),反应温度为35℃,反应时间为6.5 h,套用次数不超过8次。优化条件下,中间体3收率95.5%,纯度98.5%。Baclofen was prepared by Henry condensation,Michael addition, catalytic hydrogenation and decarboxylation with para-chlorobenzaldehyde and methylmalonate as raw materials. The reaction conditions were optimized as follows, Raney's Ni as catalyst, 10%(m/m), reaction temperature 35℃, reaction time 6.5 h, application number not more than 8 times, with intermediate 3 yield of 95.5% and purity of 98.5%.

关 键 词：巴氯芬 雷尼镍 催化加氢 

分 类 号：TQ463[化学工程—制药化工]