连续法合成N,N’,N’’,N’’’-四苄基环烯  

Synthesis of N,N’,N’’,N’’’-Tetrabenzylcyclene by Continuous Method

作　　者：杨学军 杜渭松 高嫒嫒 别国军 张严伟 黄劳劳 陈少青 YANG Xue-jun;DU Wei-song;GAO Ai-ai;BIE Guo-jun;ZHANG Yan-wei;HUANG Lao-lao;CHEN Shao-qing(Xi'an Caijing Opto-Electrical Science&Technology Co., Ltd., Xi'an 710065, China)

机构地区：[1]西安彩晶光电科技股份有限公司

出　　处：《精细化工中间体》2018年第5期55-58,共4页Fine Chemical Intermediates

摘　　要：以乙醇胺、氯化苄为原料,经过N-苄基乙醇胺、N-苄基乙醇胺磺酸酯、N-苄基氮丙啶等中间体的合成,连续法合成医药中间体N,N',N'',N'''-四苄基环烯,其结构经IR、1HNMR、13CNMR和HRMS确证。中间体无需分离及纯化处理,4步反应总收率35.5%,高于文献收率。Using ethanolamine and benzyl chloride as the raw materials, the pharmaceutical intermediate N,N',N'',N'''-tetrabenzylcyclene was synthesized in a four-step continuous reaction, the product structure was confirmed by IR, 1H NMR, 13C NMR and HRMS. There was no requirement for separation and purification of the intermediates including N-benzylethanolamine, N-benzylethanolamine sulfonate and N-benzylethanolamine. A total yield of the whole four steps reaction was up to 35.5%.

关 键 词：N N' N'' N'''-四苄基环烯 N-苄基氮丙啶 N-苄基乙醇胺磺酸酯 N-苄基乙醇胺 连续法 

分 类 号：TQ463.4[化学工程—制药化工]