HMGB1在哮喘‐慢性阻塞性肺疾病重叠综合征患者的表达及意义  

Expression and significance of HMGB1 in patients with asthma‐COPD overlap syndrome

作　　者：金林[1] 赵芝焕[2] 宋小舟[3] 谭芳[1] Jin Lin;Zhao Zhihuan;Song Xiaozhou;Tan Fang(No .1 Age Respiratory of Medicine ,the First Affiliated Hospital of Kunming Medical University ,Kunming 650000,China)

机构地区：[1]昆明医科大学第一附属医院老年呼吸一科,650000 [2]昆明医科大学第一附属医院老年呼吸二科,650000 [3]云南省第一人民医院感染管理科,昆明650000

出　　处：《国际呼吸杂志》2018年第23期1771-1774,共4页International Journal of Respiration

摘　　要：目的探讨血清高迁移率族蛋白B1(HMGB1)在哮喘‐慢性阻塞性肺疾病重叠综合征(ACOS)患者中的表达水平及意义。方法按照入组标准纳入50例单纯哮喘急性发作期患者(哮喘组)、50例单纯慢性阻塞性肺疾病急性加重期患者(COPD组)以及50例ACOS急性加重期患者(ACOS组);抽取入选者全血,检测HMGB1(ELISA法)水平,外周血白细胞总数及C反应蛋白浓度。结果白细胞总数、C反应蛋白及HMGB1浓度在ACOS组最高、哮喘组次之,COPD组最低,3组间比较差异有统计学意义(P<0.01)。ACOS组患者血清HMGB1水平与CRP、WBC均呈正相关(r=0.438,P=0.001;r=0.431,P=0.008);ACOS、COPD、哮喘组内血HMGB1与FEV1均无明显相关性(P>0.05)。ACOS组中HMGB1与FEV1%pred呈显著负相关(r=-0.651,P<0.01),HMGB1与FEV1/FVC呈显著负相关(r=-0.785,P<0.01)。结论血清HMGB1水平在ACOS、COPD、哮喘组患者均明显升高,特别是ACOS升高水平最高,提示ACOS组患者的呼吸系统炎症严重程度高于COPD和哮喘组,并对疾病的严重程度有一定的作用。Objective To investigate the expression and significance of serum high mobility group protein B1 ( HMGB1 ) in patients with asthma‐chronic obstructive pulmonary disease overlap syndrome (ACOS) .Methods According to the criteria of enrollment ,50 patients with acute exacerbation of simple asthma (asthma group) ,50 patients with acute exacerbation of chronic obstructive pulmonary disease (COPD group) and 50 patients with acute exacerbation of ACOS ( ACOS group) were enrolled in this study .The whole blood of the selected patients was collected and the levels of HMGB 1 ( ELISA method) , total white blood cells and C‐reactive protein in peripheral blood were measured . Results The total number of white blood cells ,C‐reactive protein and HMGB1 concentration were the highest in ACOS group ,the second in asthma group ,and the lowest in COPD group .There were significant differences among the three groups ( P < 0 .01) .Serum HMGB1 level was positively correlated with CRP and WBC in ACOS group ( r = 0 .438 , P = 0 .001 ; r = 0 .431 , P = 0 .008 ) ;there was no significant correlation between HMGB1 and FEV1 in ACOS ,COPD and asthma group ( P > 0 .05) .In ACOS group ,HMGB1 was negatively correlated with FEV1 % pred ( r = - 0 .651 , P < 0 .01 ) ,and HMGB1 was negatively correlated with FEV1 /FVC ( r = - 0 .785 , P < 0 .01 ) . Conclusions Serum HMGB1 levels are significantly increased in ACOS ,COPD and asthma groups ,especially in ACOS group ,suggesting that the severity of respiratory inflammation in ACOS group is higher than that in COPD and asthma group ,and

关 键 词：高迁移率族蛋白B1 慢性阻塞性肺疾病 哮喘 哮喘‐慢性阻塞性肺疾病重叠综合征 

分 类 号：R562.25[医药卫生—呼吸系统] R563.9[医药卫生—内科学]