乌贼墨多糖抗肿瘤作用及其机制研究进展  

Research progress on the antitumor effects and mechanisms of squid ink polysaccharides

作　　者：田伟路 刘飞[1,2] 王凤山 TIAN Wei-lu;LIU Fei;WANG Feng-shan(Key Laboratory of Chemical Biology (Ministry of Education),Institute of Biochemical and Biotechnological Drugs,School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China;Shandong Academy of Pharmaceutical Sciences,Key Laboratory of Biopharmaceuticals,Engineering Laboratory of Polysaccharide Drugs,National-Local Joint Engineering Laboratory of Polysaccharide drugs,Jinan 250101,China;National Glycoengineering Research Center,Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology,Shandong University,Jinan 250012,China)

机构地区：[1]山东大学生化与生物技术药物研究所,药学院,山东济南250012 [2]山东省药学科学院山东省生物药物重点实验室,多糖类药物发酵与精制国家地方联合工程实验室,山东济南250101 [3]国家糖工程技术研究中心,山东济南250012

出　　处：《中国海洋药物》2018年第5期79-85,共7页Chinese Journal of Marine Drugs

基　　金：国家自然科学基金项目(30973678);山东省重大科技项目(2015ZDJS04001)资助

摘　　要：近年来,针对海洋来源的生物物质的药用价值进行开发,特别是用于治疗严重危害人类健康的恶性肿瘤的研究,已成为药学领域的热点之一。乌贼散布于世界各大洋,乌贼墨多糖是乌贼墨中的1种重要的生物活性成分,具有抗肿瘤、抗氧化、抗菌、抗逆转录病毒等多种功效。本文就2013-2018年国内外对乌贼墨多糖抗肿瘤功效及作用机制的研究作了系统的归纳和总结,旨在为乌贼墨多糖的深入研究、开发提供理论依据。In recent years,the development of medicinal values of biological substances from marine sources,especially the antitumor values,has become one of the hot topics in pharmaceutical research.Squid,one kind of marine animals,distribute throughout all the ocean.Polysaccharides are one kind of biologically active substances in squid ink.It has been reported that polysaccharides from squid ink possess a lot of biological activities,such as antitumor,antioxidant,antibacterial and antiretroviral.In this paper,the researches on antitumor activities and the mechanisms of squid ink polysaccharides from 2013 to 2018 were reviewed so as to provide a theoretical and evidential basis for the deeper study and development of squid ink polysaccharides.

关 键 词：乌贼墨多糖 抗肿瘤 作用机制 

分 类 号：R963[医药卫生—微生物与生化药学]