(4,4’-二苯醚二甲酸)(诺氟沙星)Cu(Ⅱ)配合物的结构及抑菌活性  

Structure and antibacterial activity of Cu(Ⅱ)complex(4,4’-diphenyl ether dicarboxylic acid)containing norfloxacin

作　　者：崔阔 王亮亮[2] 刘复新[2] 范卓文[2] 王广树[1] 张春晶[2] CUI Kuo;WANG Liang-liang;LIU Fu-xin;FAN Zhuo-wen;WANG Guang-shu;ZHANG Chun-jing(College of Pharmacy,Jilin University,Changchun 220100,China;College of Pharmacy,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]吉林大学药学院,吉林长春220100 [2]黑龙江中医药大学药学院,黑龙江哈尔滨150040

出　　处：《分子科学学报》2018年第6期497-500,I0005,共5页Journal of Molecular Science

基　　金：国家自然科学基金资助项目(21501053)

摘　　要：采用水热法合成了诺氟沙星金属配合物[Cu(C16H18N3FO3)2(C14H8O5)(H2O)3],并应用X-射线单晶衍射技术对其结构进行测定,确定了其几何构型,探讨了金属离子与药物分子的配位方式.采用琼脂扩散法对比4种常见细菌对药物的敏感性,结果表明合成的金属配合物具有一定的抑菌作用.The metal complex of norfloxacin was synthesized by hydrothermal method,and the synthesis conditions were optimized.The metal complex [Cu(C16H18N3FO3)2(C14H8O5)(H2O)3]was syn-thesized.The structure of the metal complex was determined by X-ray single crystal diffraction.The geometric configuration of the complex was determined.Agar diffusion method was used to comparethe sensitivity of four common bacteria to drugs.The synthesized metal complexes has certain bacteriostatic effect.

关 键 词：诺氟沙星 金属配合物 合成 晶体结构 抑菌作用 

分 类 号：O627[理学—有机化学]