他汀类药物与冠状动脉钙化关系的研究进展  

Research progress on the relationship between statins and coronary artery calcification

作　　者：史雨晨[1] 柳景华[1] SHI Yuchen;LIU Jinghua(Department of Cardiology,Beijing Anzhen Hospital Affiliated to Capital Medical University & Beijing Institute of Cardiopulmonary Vascular Diseases,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院心内科北京市心肺血管疾病研究所

出　　处：《中国动脉硬化杂志》2018年第12期1212-1215,共4页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81570388);国家重点基础研究发展计划(973计划)项目(2015CB554404);北京市自然科学基金项目(7142048)

摘　　要：冠状动脉钙化在冠状动脉粥样硬化、糖尿病血管病变和慢性肾脏病等多种疾病中普遍存在,他汀类药物是冠状动脉粥样硬化性心脏病等血脂代谢紊乱患者的常用药物。既往研究显示,他汀类药物可能具有抑制冠状动脉钙化的作用,而新近研究则提出相反意见。鉴于目前他汀类药物与冠状动脉钙化关系存在一定争议,故本文就冠状动脉钙化发生机制,他汀类药物与冠状动脉钙化关系及两者关系矛盾性结论成因作一分析。Coronary artery calcification is a common pathological feature in many diseases,such as coronary atherosclerosis, diabetic angiopathy and chronic kidney disease. Statins are commonly used in patients with coronary atherosclerotic heart disease and dyslipidemia. Previous studies have shown that statins may inhibit coronary artery calcification,but recent studies have suggested the opposite. In view of the disputes over the relationship between statins and coronary artery calcification,this article analyzes the mechanism of coronary artery calcification,the relationship between statins and coronary artery calcification,and the reasons of contradiction between them.

关 键 词：冠状动脉钙化 他汀类药物 冠状动脉粥样斑块 血脂代谢紊乱 

分 类 号：R5[医药卫生—内科学]