植物固醇血症致动脉粥样硬化作用研究进展  

Advances in studies on atherosclerosis induced by phytosterolemia

作　　者：温文慧 王仲华 王绿娅 匡泽民[3] WEN Wenhui;WANG Zhonghua;WANG Luya;KUANG Zemin(Department of Cardiology,Chenzhou Hospital Affiliated to University of South China,Chenzhou,Hunan 423000,China;Beijing Anzhen Hospital Affiliated to Capital Medical University & Beijing Institute of Heart Lung and Blood Vessel Diseases & Research Laboratory of Atherosclerosis,Beijing 100029,China;Department of Hypertension,Beijing Anzhen Hospital Affiliated to Capital Medical University,Beijing 100029,China)

机构地区：[1]南华大学附属郴州医院心内科,湖南省郴州市423000 [2]首都医科大学附属北京安贞医院北京市心肺血管疾病研究所动脉硬化研究室,北京市100029 [3]首都医科大学附属北京安贞医院高血压科,北京市100029

出　　处：《中国动脉硬化杂志》2018年第12期1285-1290,共6页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81670811、81471098);中国中青年临床研究基金项目(2017-CCA-VG-016);北京市卫生与健康科技成果和适宜技术推广项目(2018-TG-03)

摘　　要：血浆植物固醇水平过高会增加动脉粥样硬化性心血管疾病的风险。植物固醇血症患者由于ATP结合盒转运体G5/G8突变使血液循环中植物固醇水平较正常人升高30~100倍,很早便会出现动脉粥样硬化性疾病,除此之外植物固醇血症通常还有血液系统疾病,要及早采取正确治疗方式干预。植物固醇血症患者幼儿时期也会有极高水平低密度脂蛋白胆固醇和多部位黄色瘤,因此要注意鉴别诊断。饮食控制和依折麦布是治疗植物固醇血症的有效方式。Too high level of plasma phytosterols can increase the risk of arteriosclerotic cardiovascular disease. Because of the mutation of ATP binding cassette transporter G5 /G8,the level of phytosterol in the blood circulation of patients with phytosterolemia is 30-100 times higher than that of normal people,and they will suffer from atherosclerosis at an early age. Besides,phytosterolemia usually has diseases of the blood system,so it is necessary to take proper treatment intervention as soon as possible. Patients with phytosterolemia also have very high levels of low density lipoprotein cholesterol and multisite xanthoma in early childhood,so attention should be paid to differential diagnosis. Dietary control and ezetimibe are effective ways to treat phytosteroidemia.

关 键 词：植物固醇血症 动脉粥样硬化 鉴别诊断 治疗 

分 类 号：R54[医药卫生—心血管疾病]