电感耦合等离子体质谱法测定人血白蛋白中铝含量的不确定度评定  

Evaluation of uncertainty for the determination of aluminum in human albumin by ICP-MS

作　　者：郭雷[1,2] 周长明 宋宇[3] 丁锐 邵天舒[1,2] GUO Lei;ZHOU Chang-ming;SONG Yu;DING Rui;SHAO Tian-shu(Beijing Institute For Drug Control,Beijing 102206,China;Beijing Key Laboratory of Analysis and Evaluation on Chinese Medicine ,Beijing 102206,China;School of Pharmaceutical Sciences, Peking University,Beijing 100191,China)

机构地区：[1]北京市药品检验所,北京102206 [2]中药成分分析与生物评价北京市重点实验室,北京102206 [3]北京大学药学院,北京100191

出　　处：《中国新药杂志》2018年第24期2944-2948,共5页Chinese Journal of New Drugs

摘　　要：目的:对电感耦合等离子体质谱法(ICP-MS)测定人血白蛋白中铝(Al)含量的不确定度进行评定。方法:采用电感耦合等离子体质谱法测定人血白蛋白中铝含量,应用测量不确定度评定方法,评定不确定度来源并计算合成不确定度。结果:当取样量为1. 0 mL,铝含量为6. 357 7μg·L^(-1),k=2(95%置信度),扩展不确定度为0. 239 0μg·L^(-1),测量结果表示为:(6. 357 7±0. 239 0)μg·L^(-1)。结论:该方法适用于ICP-MS法测定人血白蛋白中铝的不确定度评定,为ICP-MS分析过程的不确定度评定提供了重要参考。Objective:To establish an uncertainty analysis method for the determination of aluminum in human albumin by ICP-MS.Methods:The content of aluminum in human albumin was determined by ICP-MS. The determination process was analyzed to identify the source of uncertainty and the combined uncertainty was calculated.Results:The aluminum content was 6.3577μg·L^-1,k =2(confidence level was 95%),and the expanded uncertainty was 0.2390μg·L^-1.The assay result of the sample was (6.3577±0.2390)μg·L^-1 Conclusion:The established method is applicable for the uncertainty evaluation of determination of aluminum in human albumin by ICP-MS,and provides important reference for the uncertainty of ICP-MS analyze.

关 键 词：电感耦合等离子体质谱 不确定度 人血白蛋白 铝 

分 类 号：R917[医药卫生—药物分析学]