不同途径局部激素给药治疗难治性全聋型突发性聋的疗效分析  

Analysis of the treatment effects of refractory sudden total frequency deafness with steroid from different topical administration routes

作　　者：宋俊[1] 张磊[1] 陈彧[1] SONG Jun;ZHANG Lei;CHEN Yu(Department of Otorhinolaryngology,the Third People's Hospital of Wuxi,Wuxi,214041, China)

机构地区：[1]无锡市第三人民医院耳鼻咽喉科,江苏无锡214041

出　　处：《临床耳鼻咽喉头颈外科杂志》2018年第24期1897-1899,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨鼓室内注射地塞米松与耳后注射甲泼尼龙琥珀酸钠治疗难治性全聋型突发性聋的疗效。方法:将48例难治性全聋型突发性聋患者随机分为A、B两组,每组24例。A组鼓室内注射地塞米松0.5ml,B组耳后骨膜下注射甲泼尼龙琥珀酸钠40mg,均为隔天给药1次,持续2周。治疗结束后2周复查听力。结果:A组治愈1例,显效2例,有效6例,无效15例,总有效率为37.5%;B组治愈0例,显效1例,有效4例,无效19例,总有效率为20.8%,两组比较差异无统计学意义(P>0.05)。两组治疗后平均听阈分别提高了(15.13±11.77)dB和(8.71±9.72)dB,两组比较差异有统计学意义(t=2.059,P<0.05)。结论:对难治性全聋型突发性聋患者,两种局部激素的给药方式均可推荐,选择鼓室内注射地塞米松可能对听阈的提高更有优势。Objective:To compare the efficacy between intratympanic dexamethasone and postauricular injection of methylprednisolone treatment for refractory sudden total frequency deafness.Method:Forty-eight cases of refractory sudden total frequency deafness were randomly divided into A group and B group(n=24 in each group).A group received intratympanic injection of dexamethasone 0.5 ml,and B group received postauricular injection of methylprednisolone 40 mg.Both treatments were performed once every other day for 2 weeks.The hearing was reviewed 2 weeks after the treatment.Result:In A group,1 case was cured,2 cases were markedly effective,6 cases were effective,15 cases were ineffective,the total effective rate was 37.5%;in B group,0 cases were cured,1 case was markedly effective,4 cases were effective,19 cases were ineffective,the total effective rate was 20.8%.There was no significant difference between the two groups in the total effective rate(P>0.05).The average PTA of patient in the A group and B group were respectively increased by(15.13±11.77)dB and(8.71±9.72)dB,and the difference was statistically significant(t=2.059,P<0.05).Conclusion:Both topical injection treatments of glucocorticoids can be recommended for patients with refractory sudden total frequency deafness,while intratympanic dexamethasone may be more advantageous in improving hearing threshold.

关 键 词：聋 突发性 鼓室注射 耳后注射 糖皮质激素类 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]