肥胖型少弱精子症的发病机制及中医调体防治  

Pathogenesis of Obesity-type Oligozoospermia and TCM Prevention and Treatment with Constitution Regulation

作　　者：董阳 孟翔鹤 王鑫[1] 郑燕飞[1] 王济[1] 赵蔚波 王琦[1] DONG Yang;MENG Xianghe;WANG Xin;ZHENG Yanfei;WANG Ji;ZHAO Weibo;WANG Qi(Beijing University of Chinese Medicine,Beijing China 100029)

机构地区：[1]北京中医药大学,北京100029

出　　处：《中医学报》2018年第12期2414-2417,共4页Acta Chinese Medicine

基　　金：国家自然科学基金项目(81503584)

摘　　要：少弱精子症是男性不育面对的主要问题,其中肥胖是诱发少弱精子症的重要病因。研究发现,肥胖者体内氧化应激水平提高,而氧化应激过程中活性氧簇过量则会影响精子数量、质量、活动度等,因而氧化应激是肥胖型少弱精子症发生发展的一个重要机制。痰湿体质和湿热体质是肥胖的易发生体质,研究发现该两种体质未病状态下即存在,因而推断通过调理肥胖易发的偏颇体质状态,可以提高机体的抗氧化能力,从而减少氧化应激对精子的损伤,进而降低肥胖型少弱精子症的发生率。Oligozoospermia is a major problem in male infertility,in which obesity is an important cause.It is found that the level of oxidative stress in obese people is increased,and the excess of reactive oxygen species in oxidative stress affects the quantity,quality and activity of sperm,so oxidative stress is one of the important mechanisms in the development of obesity-type Oligozoospermia. The Phlegm-damp and Damp-heat constitutions are obesity-prone physiques.It is found that the two physiques exist under the preconditions of diseases.Therefore,it can be inferred that by adjusting the biased constitutional state of obesity,the body's antioxidant capacity can be improved;thereby the injury to sperm damage and the incidence of obesity-type Oligozoospermia would be reduced.

关 键 词：少弱精子症 氧化应激 肥胖 痰湿体质 湿热体质 调体防治 

分 类 号：R259.974[医药卫生—中西医结合]