1968—2017年我国广州管圆线虫感染及流行因素分析  

Analysis of infection and epidemic factors of Angiostrongylus cantonensis in China from 1968 to 2017

作　　者：邢维媚 芦亚君[1] XINGWei-mei;LU Ya-jun(School of Tropical Medicine and Laboratory Medicine, Hainan Medical College, Haikou, Hainan 571199, China)

机构地区：[1]海南医学院热带医学与检验医学院

出　　处：《疾病预防控制通报》2018年第6期38-43,共6页Bulletin of Disease Control & Prevention(China)

基　　金：海南医学院科研培育基金(Y2015-08);海南省教育厅科学研究项目重点项目(Hnky2017ZD-15)

摘　　要：目的了解我国广州管圆线虫感染情况,分析其流行因素及流行特点。方法从中国知网、维普数据库和万方数据库中获取相关文献全文,遵循纳入和排出标准筛选文献,按流行情况、地区分布、年龄、性别、职业、病史行为、住院时间、误诊情况、检查方法、治疗手段、死亡情况和动物宿主感染情况等因素进行统计学分析。结果1968—2017年全国患有广州管圆线虫病共521例,分别来自于台湾、云南、四川等13个省、市、自治区;误诊病例29例;中间宿主中褐云玛瑙螺的感染率最高(25.88%),终宿主中青毛鼠的感染率最高(25.00%),中间宿主和终宿主感染情况呈显著性相关(r=0.969,P<0.001)。结论广州管圆线虫可引起嗜酸性粒细胞增多性脑膜炎,病例多发生于沿海地区,与食入未熟的中间宿主密切相关;我国许多地区是广州管圆线虫病的自然疫源地,且近年两次出现暴发性流行;加强卫生宣传教育、改变不良的饮食习惯和生活习惯对防控广州管圆线虫病十分必要。Objective To understand the infection status of Angiostrongylus cantonensis in China, and analyze its epidemic factors and characteristics. Methods The relevant literatures were obtained from CNKI, database of VIP and Wanfang according to the inclusion and exclusion standard. The factors of prevalence, regional distribution, age, gender, occupation, medical history, hospital stay, misdiagnosis, examination method, treatment, death and animal host infections were statistically analyzed. Results Totally 521 cases of Angiostrongylus cantonensis were found in 13 provinces (cities and autonomous regions) of China, such as Taiwan, Yunnan and Sichuan, etc. from 1968 to 2017. There were 29 patients misdiagnosed. The infection rate was the highest in the intermediate hosts of Achatina fulica (25.88%), and the definitive hosts of Berylmys bowersi (25.00%). The infection in the intermediate and definitive hosts showed significant correlation (r=0.969, P<0.001). Conclusions The eosinophilic meningitis can be caused by Angiostrongylus cantonensis. Patients are found more in the coastal areas and closely relate to intake of undercooked intermediate hosts. Many areas in China are the natural foci of Angiostrongylus cantonensis, and two outbreaks occurred in recent years. It is necessary to strengthen health education and change poor eating habits and lifestyle for angiostrongyliasis prevention.

关 键 词：广州管圆线虫 中间宿主 终宿主 

分 类 号：R532.1[医药卫生—内科学]