化学交换饱和转移及其在人脑成像研究中的应用进展  

Chemical exchange saturation transfer and its application progress in human brain imaging

作　　者：曾海燕 许海云 Zeng Haiyan;Xu Haiyun(Mental Health Center, Shantou University Medical College, Shantou 515041, China;Department of Psychiatry, Xiamen Xianyue Hospital (Mental Health Center of Xiamen City), Xiamen 361012, China)

机构地区：[1]汕头大学医学院精神卫生中心,515041 [2]厦门市仙岳医院(厦门市精神卫生中心)361012

出　　处：《国际生物医学工程杂志》2018年第5期443-449,共7页International Journal of Biomedical Engineering

摘　　要：化学交换饱和转移(CEST)是近年发展起来的一种核磁共振技术。其利用选择性的射频脉冲饱和可交换的氢质子,通过化学交换将饱和质子转移至自由水,导致自由水池的信号降低,从而推断溶质池信息和溶质周围的环境信息。近年来,CEST技术发展极其迅速,已研发出多种CEST对比剂,具有各自的特性和应用。将重点介绍CEST的原理、信号测定、对比剂分类,以及几种常用对比剂包括酰胺质子转移成像(APT)-CEST、谷氨酸化学交换饱和转移(gluCEST)和葡萄糖化学交换饱和转移(glucoCEST)对比剂在人脑成像研究中的应用。Chemical exchange saturation transfer(CEST) is a novel MRI technology developed in recent years. In CEST, the exchangeable hydrogen protons were saturated using a selective RF pulse, and then transferred into free water by chemical exchange. This process leads to a reduction of free pool signal, which can be used to infer the solute pool information and environmental information around the solute. In recent years, CEST technology has developed rapidly, and various CEST contrast agents have been developed with their own characteristics and applications. In this review paper, the principles, measurement of CEST signal, types of CEST agents, and the applications of several commonly used CEST contrast agents in human brain imaging researches were introduced including amide proton transfer imaging CEST (APT-CEST), glutamate CEST (gluCEST) and glucose CEST (glucoCEST).

关 键 词：磁共振成像 化学交换饱和转移 对比剂 脑代谢物 

分 类 号：R445.2[医药卫生—影像医学与核医学]