温州市2008-2017年疑似预防接种异常反应死亡病例特征  

Characteristics of deaths following immunization in Wenzhou city, 2008-2017

作　　者：陈玲萍[1] 魏晶娇[1] 孙肖瑜[1] 郑晓春[1] 李万仓[1] 王志刚[1] Chen Lingping;Wei Jingjiao;Sun Xiaoyu;Zheng Xiaochun;Li Wancang;Wang Zhigang(Wenzhou Municipal Center for Disease Control and Prevention,Wenzhou 325000,Zhejiang,China)

机构地区：[1]温州市疾病预防控制中心

出　　处：《中国疫苗和免疫》2018年第6期685-688,712,共5页Chinese Journal of Vaccines and Immunization

基　　金：温州市科技计划项目(Y20130322);温州市公益性社会发展(医疗卫生)科技项目(Y20170683)

摘　　要：目的分析温州市疑似预防接种异常反应(AEFI)死亡病例的特征。方法收集温州市2008-2017年通过全国AEFI信息管理系报告的AEFI死亡病例数据,进行描述性分析。结果 2008-2017年温州市共报告AEFI死亡病例13例,报告发生率为0.45/100万剂;其中偶合症10例(76.9%),异常反应3例(23.1%);男女性别比为2.3∶1;婴幼儿12例(92.3%),成人1例(7.7%)。婴幼儿病例接种至死亡的时间间隔中位数为17h(范围:35min-69h)。结论温州市AEFI死亡报告发生率极低,以偶合症为主。Objective To analyze clinical characteristics of deaths as adverse events following immunization (AEFIs)in Wenzhou city.Methods We collected death AEFI cases during 2008-2017 through the National AEFI Surveillance System for descriptive analysis.Results A total of 13 deaths were reported following immunization during 2008-2017 in Wenzhou,for an incidence of 0.45 cases per million doses administered.Ten (76.9%) cases were confirmed as coincidental,and 3(23.1%) were vaccine reactions.The male to female ratio was 2.3:1.Twelve (92.3%) cases were infants or young children,and 1(7.7%) was adult.The median time interval from administration to death for childhood cases was 17 hours (range:35 minutes-69 hours).Conclusions The incidence of deaths following immunization was extremely low in Wenzhou,and most were coincidental.

关 键 词：预防接种 疑似预防接种异常反应 死亡 

分 类 号：R186[医药卫生—流行病学]