芳香烃受体调节免疫应答的研究进展  

Research progress on aryl hydrocarbon receptors modulating immune responses

作　　者：么秀华[1] 徐立霞[1] 闫华[1] YA0Xiuhua;XU Lixia;YAN Hua(Tianjin Neurosurgical Institute,Tianjin 300350,China;Tianjin Neurosurgical Institute,Tianjin 300350,China;Tianfin Huanhu Hospital,Tianjin 300350,China)

机构地区：[1]天津市脑血管和神经退行性疾病重点实验室天津市神经外科研究所天津市环湖医院,300350

出　　处：《免疫学杂志》2019年第1期84-88,共5页Immunological Journal

基　　金：国家自然基金青年基金(81501035;81500936)

摘　　要：芳香烃受体(aryl hydrocarbon receptor,AhR)是一种配体激活的转录因子,可被污染物、微生物、食物和新陈代谢等提供的小分子活化。研究表明,AhR在许多免疫相关的细胞中表达,对健康和疾病的免疫应答起着重要的作用。AhR信号通路构成了环境、新陈代谢与免疫应答之间的分子桥梁。同时由于AhR活性受小分子调控,也构成治疗免疫调节的潜在目标。在这篇综述中,我们主要讨论了AhR信号通路在固有免疫应答和获得免疫应答中的作用。The aryl hydrocarbon receptor(AhR) is a ligand-activated transcription factor, which can be activated by small molecules from contaminants, microbes, food, and metabolism. Studies have revealed that AhR is expressed in many immune-related cells and plays an important role in healthy and diseased immune system.Therefore, the AhR signaling pathway constitutes a molecular bridge between the environment, metabolism and immune response. Since AhR activity is regulated by small molecules, AhR became to a potential target of the treatment of immune regulation. In this review, we mainly discuss the roles of the AhR signaling pathway in innate and adaptive immune responses.

关 键 词：芳香烃受体 芳香烃受体信号通路 固有免疫应答 获得性免疫应答 

分 类 号：R392.11[医药卫生—免疫学]