基于数据挖掘的原发性高血压中医证素及症状/体征分布规律研究  

Study on Distribution Rules of TCM Signs and Symptoms and Syndrome Elements in Essential Hypertension Based on Data Mining

作　　者：张洋[1] 雷蕾[2] 何建成[1] ZHANG Yang;LEI Lei;HE Jiancheng(Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beo'ing 100700,China)

机构地区：[1]上海中医药大学,上海201203 [2]中国中医科学院中医药信息研究所,北京100700

出　　处：《中国中医药信息杂志》2019年第1期99-104,共6页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(30873398);上海市博士点建设基金(K110412)

摘　　要：目的分析原发性高血压(EH)中医证素、症状/体征的分布规律及相关关系,为临床诊断提供参考。方法采用临床横断面研究方法,收集上海中医药大学附属龙华医院、上海中医药大学附属普陀医院和上海市王港社区医院2014年4月-2015年10月门诊及住院收治的EH患者症状/体征信息,按照《证素辨证学》进行证素辨证。采用SPSS21.0进行统计分析、Apriori算法进行关联规则分析、Cytoscape3.2进行复杂网络分析。结果纳入病例1192例,涉及中医证素17种、症状/体征78种。具强关联关系的证素有3组:脾、气虚、痰、湿;肝、肾、阴虚、阳亢;心、肾、精亏、气虚。男性与女性EH患者的证素组合存在差异。核心证素有心、肝、脾、肾等7种;症状/体征有头痛、头晕、胸闷、胸痛等29种。结论 EH中医证素和症状/体征分布存在一定规律,部分证素和症状/体征对其诊断具核心作用。Objective To analyze the distribution rules and relevant relation of TCM signs and symptoms (SSs)and syndrome elements (SEs)in essential hypertension (EH);To provide references for clinical diagnosis.Methods The clinical cross-sectional study method was used to collect the signs and symptom of EH patients from the Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine,Putuo Hospital affiliated to Shanghai University of Traditional Chinese Medicine and Shanghai Wanggang Community Hospital from April 2014 to October 2015.The data were under syndrome differentiation according to Zheng Su Bian Zheng Xue.SPSS21.0 was used for statistical analysis,Apriori algorithm for association rule analysis,and Cytoscape3.2 for complex network analysis.Results Totally 1192 medical cases were included in the study,involving 17SEs and 78SSs.There were three groups of SEs with strong association:spleen,qi deficiency,phlegm,dampness;liver,kidney,yin deficiency, hyperactivity of yang;heart,kidney,deficiency of kidney essence,qi deficiency.There was a difference in the combination of SEs between male and female EH patients.There were 7 SEs with core status:heart,liver,spleen, kidney,etc.29SSs with core status:headache,dizziness,chest tightness and chest pain,etc.Conclusion There were certain regularities in the distribution ofTCM SEs and SSs in EH patients.Some SEs and SSs have the core role in the diagnosis of EH.

关 键 词：原发性高血压 中医证素 症状 体征 数据挖掘 

分 类 号：R2-05[医药卫生—中医学] R259.441