急性肾损伤患者血清Klotho和FGF-23水平与肾功能转归及预后的关系  

Correlation of serum Klotho,FGF-23 levels and renal function outcomes and prognosis of patients with acute kidney injury

作　　者：郭红萍[1] 高洁 李海端 Guo Hongping;Gao Jie;Li Hairui(Department of Nephrology,Linfen People's Hospital,Linfen 041000,China)

机构地区：[1]山西省临汾市人民医院肾脏内科,041000

出　　处：《中国实用医刊》2018年第23期24-27,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨急性肾损伤患者血清Klotho和成纤维细胞生长因子23(FGF-23)水平与肾功能转归及预后的关系。方法选择2016年9月至2018年3月临汾市人民医院收治的208例急性肾损伤患者作为研究对象,观察其血清Klotho、FGF-23水平及其他相关因素和肾功能恢复的相关性。结果208例患者出院时肾功能恢复156例(恢复组),未恢复52例(未恢复组)。恢复组Klotho水平高于未恢复组,FGF-23水平低于未恢复组,差异有统计学意义(P<0.05)。单因素分析显示,恢复组和未恢复组患者糖尿病、血糖、血钾、血钙等指标比较差异未见统计学意义(P>0.05),性别、年龄、高血压、心血管疾病、患者来源、急性肾损伤分期、少尿、肾外器官衰竭、收缩压、舒张压、机械通气、血红蛋白、血清白蛋白、血肌酐、血尿素氮等指标比较差异均有统计学意义(P均<0.05)。多因素二分类logistic分析结果显示,FGF-23>467.2pg/dl、急性肾损伤分期3期、肾外器官衰竭是影响急性肾损伤患者肾功能未恢复的独立危险因素(P<0.05),血清白蛋白>35g/L、Klotho>1.23μg.L是急性肾损伤患者肾功能未恢复的保护性因素(P<0.05)。结论Klotho和FGF-23水平对急性肾功能损伤的预后具有预测价值,值得进一步研究探讨。Objective To study the correlation between serum Klotho,FGF-23 levels and renal function outcomes and prognosis of patients with acute kidney injury.Methods A total of 208 patients with acute kidney injury treated in Linfen People's Hospital from September 2016 to March 2018were selected as research subjects.And the correlation between Klotho and FGF-23 levels,medical records and renal function recovery were observed.Results Of the 208 patients,renal function recovered in 156 cases (recovery group),and hadn't recovered in 52 cases (non-recovery group).The level of Klotho in recovery group was higher than that in non recovery group,and the level of FGF-23was lower than that in non recovery group,and the difference was statistically significant (P<0.05).Univariate factor analysis showed that there was no significant difference in diabetes,blood sugar,blood potassium or blood calcium in recovery group and non-recovery group (P>0.05),and there were significant differences in gender,age,hypertension,cardiovascular disease,patients'origin,staging,oliguria,renal failure, systolic and diastolic pressure,mechanical ventilation,hemoglobin,serum albumin,serum creatinine, blood urea nitrogen and other indicators between the two groups (P<0.05).The results of multivariate factor two classification logistic analysis showed that FGF-23>467.2pg/dl,stage 3 of acute renal injury,and external renal failure were independent risk factors affecting the renal failure in patients with acute renal injury (P<0.05),and the serum albumin >35g/L,and Klotho>1.23μg/L were the protection factors of renal failure in patients with acute renal injury (P<0.05).Conclusions The Klotho and FGF-23levels have predictive value for the prognosis of acute renal injury,which deserve further study.

关 键 词：急性肾损伤 肾功能 KLOTHO 成纤维细胞生长因子23 

分 类 号：R692[医药卫生—泌尿科学]