不同分型热性惊厥的临床及病原学特点比较  

Comparison of clinical and pathogenic characteristics of different types of febrile seizures

作　　者：覃甜甜 周杰林 QIN Tian-tian;ZHOU Jie-lin(NO.1Internal Medicine Department,Hangzhou Children's Hospital,Zhej iang Hangzhou 310014,China)

机构地区：[1]杭州市儿童医院内一科,浙江杭州310014

出　　处：《中国妇幼健康研究》2018年第12期1530-1533,共4页Chinese Journal of Woman and Child Health Research

摘　　要：目的比较儿童单纯性热性惊厥(SFS)与复杂性热性惊厥(CFS)的临床特点及病原学分布。方法选取杭州市儿童医院2017年9月至2018年2月期间收治并临床确诊为热性惊厥(FS)的166例患儿为研究对象,将研究对象分为SFS组(118例)与CFS组(48例),比较两组患儿的临床特点及病原学分布。结果不同分型FS患儿性别构成无显著差异(χ2=1.88,P>0.05),SFS患儿发病年龄显著小于CFS患儿,差异显著(t=-5.24,P<0.01);SFS患儿发作体温显著高于CFS患儿,发病频率及发病持续时间均显著低于CFS患儿,差异均有统计学意义(t值分别为15.24、-11.50、-3.89,均P<0.01)。SFS组血清钠水平显著高于CFS组,差异有统计学意义(t=2.43,P<0.05);SFS组血清钾、氯、磷、镁水平均高于CFS组,但差异均无统计学意义(均P>0.05);SFS组血清钙水平及血氨浓度均低于CFS组,但差异均无统计学意义(均P>0.05)。SFS患儿脑电图异常率显著低于CFS患儿,差异具有统计学意义(χ2=5.22,P=0.02)。166例患儿中共有104例患儿病原学检出阳性,阳性率为62.65%(104/166),共检出病原体182株,其中细菌5株,病毒129株,支原体43株,衣原体5株。SFS组细菌检出率低于CFS组,但差异不显著(P>0.05),SFS组病毒、肺炎支原体、肺炎衣原体检出率均高于CFS组,但差异均无统计学意义(均P>0.05)。结论不同类型的FS患儿的临床特点、脑电图异常情况存在一定的差别,临床上对FS的诊疗及防治过程中,应注意SFS与CFS的鉴别诊断。Objective To compare the clinical characteristics and pathogenic distribution of children with simple febrile seizures (SFS)and complex febrile seizures (CFS).Methods A total of 166 children with febrile seizures (FS)who were admitted to Hangzhou Children's Hospital from September 2017 to February 2018 were enrolled.The subjects were divided into SFS group (118 cases)and CFS group (48 cases)to compare the clinical characteristics and pathogenic distribution.Results There was no significant difference in gender composition between children with different types of FS (x^2=1.88,P >0.05).The onset age of SFS was significantly lower than that of CFS (t=-5.24,P<0.01).Compared with children with CFS,those with SFS had higher onset temperature but lower frequency and shorter duration of disease with significant differences (t value was 15.24,-11.50and -3.89,respectively,all P<0.01).The serum sodium level in the SFS group was significantly higher than that in the CFS group (t=2.43,P<0.05).The serum potassium,chloride,phosphorus and magnesium levels in the SFS group were higher than those in the CFS group,but the differences were not statistically significant (all P >0.05).The serum calcium level and blood ammonia concentration in the SFS group were lower than those in the CFS group,but the differences were not statistically significant (both P >0.05).The abnormal rate of EEG in children with SFS was remarkably lower than that in children with CFS,and the difference was significant (x^2=5.22,P=0.02).A total of 104 children in 166 children were positive for pathogens,with a positive rate of 62.65%(104/166),and 182 pathogens were detected,including 5 strains of bacteria,129 strains of virus,43 strains of mycoplasma,and 5strains of chlamydia.The detection rate of bacteria in SFS group was lower than that in CFS group,but the difference was not significant (P >0.05).The detection rates of virus,mycoplasma pneumoniae and chlamydia pneumoniae in the SFS group were higher than those in the CFS group,but the differences were not s

关 键 词：单纯性热性惊厥 复杂性热性惊厥 临床特点 病原学分布 

分 类 号：R725[医药卫生—儿科]