从转化医学角度谈银屑病发病模式转换及治疗进展  

Paradigm Shift and Treatment Progress of Psoriasis from Translational Medicine Perspective

作　　者：滕艳 刘毅[1] TENG Yan;LIU Yi(Institute of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical Colleges, Nanjing 210042,China)

机构地区：[1]中国医学科学院皮肤病医院临床药理及化妆品检测中心,江苏南京210042

出　　处：《中国皮肤性病学杂志》2019年第1期1-5,共5页The Chinese Journal of Dermatovenereology

摘　　要：银屑病发病机制复杂,尚未完全阐明。自1979年环孢素被发现用于治疗银屑病后,对银屑病发病机制的认识也由一种增殖分化异常性疾病(即角质形成细胞模式)向免疫相关性疾病(T细胞模式)转变。随着研究深入,T细胞模式中Th1、Th17、Th22、Treg、γδT细胞的作用逐渐被揭示,针对部分细胞及其相关细胞因子已开发出相应药物。The pathogenesis of psoriasis is complicated and has not been fully elucidated. Since cyclosporin has been used to treat psoriasis,the understanding of its pathogenesis is also transforming from an epidermal proliferative disease (keratinocyte paradigm) to an immune-related disease(T-cell paradigm). With the development of research,the function of Th1,Th17,Th22,Treg,and γδT cell in the T cell paradigm has been revealed,and new drugs have developed based on some of these cells and related cytokines. The paradigm shift and treatment progress of psoriasis in a perspective of translational medicine were summarized.

关 键 词：转化医学 银屑病 发病模式 治疗进展 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]