导电聚合物神经电极涂层进展  

Conducting Polymer Neural Interface Probe Coating

作　　者：王莉萍[1] 王瑾晔[1] WANG Li-ping;WANG Jin-ye(Shanghai Jiaotong University,School of Biomedical Engineering,Shanghai 200024,China)

机构地区：[1]上海交通大学生物医学工程学院,上海200024

出　　处：《高分子通报》2019年第1期102-109,共8页Polymer Bulletin

基　　金：科技部国际科技合作计划项目(2014DFG02330;2015DFG32730);上海市科学技术委员会(13JC1403400;15540723900);上海市教育委员会(高峰生物医学工程资助;ZXGF082101)

摘　　要：神经电极的发展受到了生物医学工程、神经生物学以及相关临床医学等领域的关注。现有的神经电极面临电信号失效、手术植入后的组织反应等问题。为了使电极-神经组织界面维持良好的电学性能,以保证其长期有效性,需要对电极进行改性,除了改变电极本身微观结构外,合成导电性新材料作为电极表面的涂层也是一种有效的解决方案。导电聚合物易于合成、具有良好的导电性能与生物相容性,用其直接修饰或经与其它材料杂化后作为涂层可显著提高电极的电化学性能。本文对导电聚合物神经电极涂层的研究进展进行介绍。The development of neural electrodes has received increasing attention in areas such as biomedical engineering,neuroscience,and related clinicaI medicine.Traditional neural electrodes face electrical signal failures, resulting in a series of tissue responses.In order to make the nerve probe-nerve interface with good electrical properties,to ensure its long-term effectiveness,we need to use the surface coating to modify the electrode,including to modify the electrode microstructure or to find new materials.Conductive polymers are easy to synthesize and own conductive performance and good biocompatibility,the electrochemical performance could be improved significantly by coating of conductive polymers and their composites.The recent progress of conductive polymers as neural electrode coating is introduced in this paper.

关 键 词：神经电极涂层 导电聚合物 碳纳米管 生物活性涂层 

分 类 号：R318.08[医药卫生—生物医学工程] O631[医药卫生—基础医学] TH77[理学—高分子化学]