卵母细胞内注射自体骨髓线粒体获得男婴活产1例病例报道  

A case of transferring mitochondria from autologous bone mesenchymal stem cells into oocytes resulting in a live baby boy

作　　者：方丛[1] 黄睿[1] 贾磊[1] 曹国坤 刘晓娉 陈伟熙 梁晓燕[1] Fang Cong;Huang Rui;Jia Lei;Cao Guokun;Liu Xiaoping;Chen Weixi;Liang Xiaoyan(Reproductive Medicine Research Center,the Sixth Affiliated Hospital of Sun Yat-sen University,Guangzhou 510655,China)

机构地区：[1]中山大学附属第六医院生殖医学研究中心,广州510655

出　　处：《中华生殖与避孕杂志》2018年第11期937-939,共3页Chinese Journal of Reproduction and Contraception

摘　　要：目的探讨卵母细胞内注射自体骨髓线粒体对不孕患者反复助孕失败的治疗效果。方法对本中心1例反复助孕失败不孕患者的临床资料进行分析,介绍卵母细胞内注射自体骨髓线粒体的过程。结果患者孕34^(+5)周活产一男婴。结论卵母细胞内注射自体骨髓线粒体为解决原发不孕夫妇胚胎质量差及妊娠结局差等问题提供了新思路。Objective To explore the effect of transferring mitochondria from autologous bone mesenehymalstem cells on repeated pregnancy failure in infertility.Methods The clinical materials of an infertile patient undergoing repeated failure in in vitro fertilization (IVF)cycles was analyzed,and the process of transferring mitochondria from autologous bone mesenchymal stem ceils (BMSCs)into oocytes was introduced.Results The patient underwent low-segment cesarean section at 34^+5weeks of gestation and obtained a live baby boy.Conclusion Transferring mitochondria from autologous BMSCs into oocytes offers a new potential treatment to improve embryo quality and IVF outcome for infertile couples.

关 键 词：骨髓间充质干细胞 线粒体移植 卵母细胞质量 胚胎质量 

分 类 号：R714.8[医药卫生—妇产科学]