无机纳米材料在骨组织工程与再生医学中的应用  

Application of inorganic nanomaterials in bone tissue engineering and regenerative medicine

作　　者：靳祎[1,3] 葛昆 刘丹丹[1,2] 张金超[1,2] 刘会芳[1,4] 梁兴杰[5] Yi Jin;Kun Ge;Dandan Liu;Jinchao Zhang;Huifang Liu;Xingjie Liang(Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education,Hebei University,Baoding 071002,China;College of Chemistry &Environmental Science,Hebei University,Baoding 071002,China;Medical College,Hebei University,Baoding 071002,China;College of Pharmacy,Hebei University,Baoding 071002,China;Laboratory for Biological Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology,Chinese Academy of Sciences,Beijing 100190,China)

机构地区：[1]河北大学,药物化学与分子诊断教育部重点实验室,保定071002 [2]河北大学化学与环境科学学院,保定071002 [3]河北大学医学院,保定071002 [4]河北大学药学院,保定071002 [5]国家纳米科学中心,中国科学院纳米生物效应与安全性重点实验室,北京100190

出　　处：《科学通报》2018年第35期3808-3824,共17页Chinese Science Bulletin

基　　金：国家自然科学基金(31500812,31470961);河北省自然科学基金(B2017201230);河北省高等学校科研项目(QN2015230);留学回国人员科技活动择优资助项目(CG2015003009);河北大学开放实验室项目(sy201664);国家自然科学基金-马普研究基金(31761133013)资助.

摘　　要：自组织工程与再生医学概念提出以来,组织工程与再生医学特别是骨组织工程与再生医学得到了突飞猛进的发展.支架材料作为骨组织工程与再生医学三要素之一扮演着至关重要的角色.10余年来,大量的研究工作围绕支架材料展开.纳米生物材料尤其是无机纳米生物材料,具有优良的机械性能和生物相容性,成为制备骨组织工程与再生医学支架材料的理想选择,呈现出广阔的应用前景.本文对近年来无机纳米材料,包括羟基磷灰石、硅基纳米材料,含碳纳米材料及几种金属纳米材料在骨组织工程与再生医学中的应用进行综述.Recently,tissue engineering and regenerative medicine,especially bone tissue engineering and regenerative medicine have developed rapidly.Bone tissue engineering is a complicated and dynamic bone remodeling process that starts with recruitment and migration of osteoblasts and then regulates their proliferation,differentiation,and mineralization.Scaffold is typically biodegradable material that plays a crucial role as one of the three elements of bone tissue engineering and regenerative medicine. Bone scaffold provides the mechanical support during reformation and repair of damaged or diseased bone.For more than a decade,a large amount of research work has been carried out on the designing of scaffolds,processing techniques,performance assessment,and medical application.Significant progress has been made toward scaffold materials for structural support for desired osteogenesis and angiogenesis abilities.To date,depending on the advanced technologies,the bioresorbable scaffolds possess controlled porosity and high mechanical properties are possible used as bone scaffold. Natural bone has delicate architectural structure that spans nanoscale to macroscopic dimensions,which determine the unique mechanical properties of bone.The hierarchical structure of natural bone can be defined as a nanocomposite consisting of inorganic nanocrystalline hydroxyapatite (HA),organic components (mostly are collagens)and water.The outside proteins assemble together to form an extracellular matrix (ECM)with nanostructured which influences the adhesion,proliferation,differentiation,and mineralization of several cell types,such as bone lining cell,mesenchymal stem cells,osteoblasts,osteocytes, and osteoclasts.To better mimic the nanostructure in natural ECM,many research groups over the past decade developed nano-based scaffolds (nanotubes,nanofibers,nanoparticles,and hydrogel)to resemble the ECM for promising candidates in replacing defective tissues.The high biomimetic properties and excellent mechanical features of nano-based scaffolds

关 键 词：无机纳米材料 骨组织工程与再生医学 支架 

分 类 号：R318.08[医药卫生—生物医学工程]