氨氯地平阿托伐他汀钙片治疗高血压合并冠心病伴颈动脉粥样硬化的效果观察  

Analysis of efficacy of amlodipine atorvastatin calcium tablets in the treatment of patients with hypertension and coronary heart disease complicated with carotid atherosclerosis

作　　者：张丽[1] 包成梅[1] 尹承华[1] 张林忠[2] Zhang Li;Bao Chengmei;Yin Chenghua;Zhang Linzhong(Department of Internal Medicine,the Second People's Hospital of Ji'nan,Ji'nan,Shandong 250001,China;Department of Cardiology,the Central Hospital of Ji'nan,Ji'nan,Shandong 250013,China)

机构地区：[1]济南市第二人民医院内科,山东省济南250001 [2]济南市中心医院心内科,山东省济南250013

出　　处：《中国基层医药》2018年第24期3180-3184,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：山东省济南市科技计划项目(2011-03).

摘　　要：目的探索氨氯地平阿托伐他汀钙片治疗高血压合并冠心病伴颈动脉粥样硬化效果。方法选取2013年8月至2017年8月济南市第二人民医院收治的高血压合并冠心病伴颈动脉粥样硬化患者280例,采用信封随机化分组模式分为两组,各140例。对照组进行苯磺酸氨氯地平片治疗,观察组进行氨氯地平阿托伐他汀钙片治疗。比较两组患者的不良反应发生率、舒张压水平、收缩压水平、总有效率、高敏C反应蛋白(hs-CRP)水平、胆固醇(TC)水平、甘油三酯(TG)水平、高密度脂蛋白胆固醇(HDL-C)水平、低密度脂蛋白胆固醇(LDL-C)、内-中膜厚度(IMT)、斑块体积(PV)。结果两组治疗前PV、IMT、收缩压、舒张压差异均无统计学意义(t=1.150、0.861、0.195、0.637,均P>0.05)。治疗后观察组不良反应发生率(2.86%)、舒张压水平[(78.95±3.11)mmHg]、收缩压水平[(121.63±5.42)mmHg]、总有效率(96.43%)、hs-CRP水平[(4.15±1.65)mg/L]、TC水平[(3.28±1.98)mmol/L]、TG水平[(1.22±0.34)mmol/L]、HDL-C水平[(1.98±0.75)mmol/L]、LDL-C水平[(1.33±0.54)mmol/L]、IMT[(1.12±0.05)mm]、PV[(0.11±0.03)cm3]均优于对照组(χ^2=22.630、t=15.839、37.209、χ^2=25.053、t=20.056、7.381、8.659、15.110、21.951、15.665、12.951,均P<0.05)。结论对高血压合并冠心病伴颈动脉粥样硬化患者实施氨氯地平阿托伐他汀钙片治疗效果显著。Objective To explore the effect of amlodipine atorvastatin calcium tablets in the treatment of patients with hypertension and coronary heart disease complicated with carotid atherosclerosis. Methods From August 2013 to August 2017,280 patients with hypertension and coronary heart disease complicated with carotid atherosclerosis in the Second People's Hospital of Ji'nan were selected,and they were divided into two groups by envelope randomization packet mode,with 140 cases in each group.The control group was treated with amlodipine benzenesulfonate.The observation group was treated with amlodipine atorvastatin calcium tablets.The incidence of adverse reactions,diastolic blood pressure(DBP) level,systolic blood pressure(SBP) level,total effective rate,hs-CRP,TC,TG,HDL-C,LDL-C,IMT,PV were compared between the two groups. Results There were no statistically significant differences in PV,IMT,SBP and DBP between the two groups (t=1.150,0.861,0.195,0.637,all P>0.05).The incidence rate of adverse reactions(2.86%),DBP level[(78.95±3.11)mmHg],SBP level[(121.63±5.42)mmHg],total effective rate (96.43%),hs-CRP levels[(4.15±1.65)mg/L],TC level[(3.28±1.98)mmol/L],TG level[(1.22±0.34)mmol/L],HDL-C level[(1.98±0.75)mmol/L],LDL-C level[(1.33±0.54)mmol/L],IMT[(1.12±0.05)mm],PV[(0.11±0.03)cm3]in the observation group were better than those in the control group(χ2=22.630,t=15.839,37.209,χ2=25.053,t=20.056,7.381,8.659,15.110,21.951,15.665,12.951,all P<0.05). Conclusion The effect of amlodipine atorvastatin calcium tablets in the treatment of patients with hypertension and coronary heart disease complicated with carotid atherosclerosis is remarkable.

关 键 词：高血压 冠状动脉疾病 动脉粥样硬化 颈动脉 氨氯地平 阿托伐他汀 血压 疗效比较研究 

分 类 号：R541.4[医药卫生—心血管疾病] R544.1[医药卫生—内科学]