甲状腺结节1476例临床分析  

A clinical analysis of 1476 cases with thyroid nodules

作　　者：吴丹妮 胡蕴[2] 毛晓明[2] WU Danni;HU Yun;MAO Xiaoming(Department of Endocrinology,First People's Hospital of Changzhou ,Changzhou 213003,CHINA)

机构地区：[1]常州市第一人民医院内分泌科,江苏213003 [2]南京医科大学附属南京医院内分泌科

出　　处：《江苏医药》2018年第12期1380-1383,共4页Jiangsu Medical Journal

摘　　要：目的分析良性甲状腺结节与甲状腺癌的临床特征。方法回顾性分析1 476例甲状腺结节手术患者的临床资料。结果 1 476例中,病理诊断为良性结节1 179例(79.88%),甲状腺癌297例(20.12%)。与甲状腺良性结节组比较,甲状腺癌组患者发病年龄小,促甲状腺激素(TSH)及甲状腺球蛋白抗体(TG-Ab)水平较高,甲状腺球蛋白(TG)水平偏低,结节最大径较小,结节钙化率和血供丰富结节比例较高(P<0.05)。Logistic回归分析显示,年龄小、高TG-Ab、结节单发、小结节、结节内钙化是甲状腺癌发生的危险因素(P<0.05)。相关性分析显示,甲状腺癌与TG-Ab和结节内钙化呈正相关(r=0.151、0.357,P<0.01),与年龄、结节个数和大小呈负相关(r=-0.209、-0.176和-0.190,P<0.01)。结论对于年轻、血清TSH及TG-Ab水平升高、单发小结节、结节内钙化的甲状腺结节患者需要警惕甲状腺癌的可能。Objective To analyze clinical characteristics of benign and malignant thyroid glands.Methods Clinical data of 1476 patients underwent the surgery for thyroid nodules were retrospectively analyzed.Results Of 1476 cases,1179 cases (79.88%)were diagnosed pathologically as benign thyroid glands (group A)and 297 cases (20.12%)as malignant thyroid glands (group β). Compared to group A,the patients in group B had a younger age,higher levels of thyroid stimulating hormone (TSH)and thyroglobulin antibody (TG-Ab),lower level of thyroid globulin (TG),less diameter of the nodes,higher percentages of nodular calcification and rich blood supply (P<0.05). Logistic analysis showed that younger age,high TG-Ab,nodules solitary,small nodule and intranodule calcification were the risk factors for thyroid carcinoma (P<0.05).Correlation analysis showed that thyroid cancer was positively correlated to the TG-Ab level and nodule calcification (r=0.151and 0.357,P<0.01),and negatively correlated to the age,number and size of the nodules (r=-0.209, -0.176and -0.190,P<0.01).Conclusion Attention should be paid to the occurrence of thyroid cancer in the patients with thyroid glands,who are the youngers and have elevated levels of TSH and TG-Ab,single nodule and nodule calcification.

关 键 词：甲状腺结节 甲状腺癌 甲状腺球蛋白 

分 类 号：R581[医药卫生—内分泌]