清胰利胆颗粒联合异甘草酸镁治疗急性胰腺炎的临床研究  

Clinical study of Qingyi Lidan Granules combined with magnesium isoglycyrrhizinate in treatment of acute pancreatitis

作　　者：邵秉政 姜琦[1] 陈林[1] 李翔[1] SHAO Bing-zheng;JIANG Qi;CHEN Lin;LI Xiang(Department of Gastrgenterology,Dongtai People's Hospital,Yaneheng 224200,China)

机构地区：[1]东台市人民医院消化内科,江苏盐城224200

出　　处：《现代药物与临床》2018年第12期3196-3199,共4页Drugs & Clinic

摘　　要：目的探讨清胰利胆颗粒联合异甘草酸镁注射液治疗急性胰腺炎的临床疗效。方法选取2015年12月—2017年12月东台市人民医院收治的120例急性胰腺炎患者作为研究对象,将患者随机分为对照组和治疗组,每组各60例。对照组患者静脉滴注异甘草酸镁注射液,将10 mg溶于10%葡萄糖注射液250 m L中,1次/d。治疗组在对照组治疗的基础上口服清胰利胆颗粒,1袋/次,3次/d。两组患者均持续治疗14 d。观察两组患者的临床疗效,比较两组的临床症状缓解时间、血清炎性因子水平和生化指标水平。结果治疗后,对照组和治疗组的总有效率分别为76.67%、93.33%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患者腹水消失时间、腹痛消失时间、排气恢复时间、尿淀粉酶恢复时间和血淀粉酶恢复时间显著短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组血清炎性因子水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清淀粉酶(AMS)、血清脂肪酶(LPS)水平均显著降低,对氧磷酶1(PON1)水平显著升高,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组生化指标明显优于对照组,两组比较差异具有统计学意义(P<0.05)。结论清胰利胆颗粒联合异甘草酸镁注射液治疗急性胰腺炎疗效显著,能有效缓解患者临床症状,改善血清炎性因子水平和相关生化指标,具有一定的临床推广应用价值。Objective To investigate the clinical effect of Qingyi Lidan Granules combined with Magnesium Isoglycyrrhizinate Injection in treatment of acute pancreatitis. Methods Patients(120 cases) with acute pancreatitis in Dongtai People’s Hospital from December 2015 to December 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were iv administered with Magnesium Isoglycyrrhizinate Injection, 10 mg added into 10% glucose injection 250 mL, once daily. Patients in the treatment group were po administered with Qingyi Lidan Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the remission time of clinical symptoms, serum inflammatory factors, and the biochemical indexes levels in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 76.67% and 93.33%, respectively, and there were differences between two groups(P < 0.05). After treatment, the ascites disappearance time, abdominal pain disappearance time, exhaust recovery time, urinary amylase recovery time, and blood amylase recovery time in the treatment group was significantly shorter than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the hs-CRP, TNF-α, and IL-6 levels in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the serum inflammatory factors in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). After treatment, AMS and LPS levels in treatment group were significantly decreased, but PON1 levels were significantly increased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the biochemical indexes levels in the treatment group after treatment

关 键 词：清胰利胆颗粒 异甘草酸镁注射液 急性胰腺炎 临床症状缓解时间 炎性因子 C反应蛋白 肿瘤坏死因子-α 白细胞介素-6 生化指标 淀粉酶 

分 类 号：R975[医药卫生—药品]