替格瑞洛致呼吸抑制2例  

Ticagrelor-induced respiratory depression:two cases report

作　　者：赵娴 张培[2] 王雨来 卢振[1] 孙海燕[3] Zhao Xian;Zhang Pei;Wang Yulai;Lu Zhen;Sun Haiyan(Department of Pharmacy, Huangshi Central Hospital of Edong Healthcare Affiliated to Hubei Polytechnic University, Huangshi 435000, China;Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China;Department of Pharmacy,Yantai Yuhuangding Hospital,Yantai 264000,China)

机构地区：[1]湖北理工学院附属鄂东医疗集团黄石市中心医院药学部,435000 [2]中国药科大学药物质量与安全预警教育部重点实验室,南京210009 [3]烟台毓璜顶医院药学部,264000

出　　处：《药物不良反应杂志》2018年第6期442-443,共2页Adverse Drug Reactions Journal

摘　　要：2例男性患者(例1,75岁;例2,63岁)因急性冠状动脉综合征行经皮冠状动脉介入治疗。为防止支架血栓形成,术后给予替格瑞洛90mg口服、2次/d。2例患者均在首次服用替格瑞洛后约4h出现胸闷和呼吸抑制,呼吸频率减慢(例1为9~12次/min,例2为9~13次/min),例1术后当晚睡眠中曾出现呼吸暂停。2例患者分别于术后第3、2天停用替格瑞洛,改用氯吡格雷,分别在停用替格瑞洛后12和10h呼吸抑制症状消失,随访3d和6d未再发作。Two male patients(patient 1,75 years old;patient 2,63 years old) underwent percutaneous coronary intervention for acute coronary syndrome.After operation,they were given ticagrelor 90 mg twice daily orally to prevent stent thrombosis.Two patients developed chest tightness and respiratory depression both about 4 hours after their first dose,with decreased respiratory rates of 9-12 and 9-13 breaths/min,respectively.In addition,patient 1 developed sleep apnea on the night after the operation.Ticagrelor was stopped and replaced by clopidogrel on the third and second day,respectively in the 2 patients.After 12 and 10 hours of ticagrelor withdrawal,the respiratory depression disappeared and did not recur at 3 and 6 days of follow-up.

关 键 词：嘌呤能P2Y12受体拮抗剂 呼吸暂停 腺苷 替格瑞洛 

分 类 号：R969.3[医药卫生—药理学]