盐酸普萘洛尔致婴儿过敏性结肠炎  

Propranolol hydrochloride-induced infantile allergic proctocolitis

作　　者：张魁山 马莉 张欣 Zhang Kuishan;Ma Li;Zhang Xin(Pediatric Hemangioma Ward, Jinan Changfeng Hemangioma Hospital, Jinan 250032, China;Pediatric Ward, Shandong Guoji Hemangioma Hospital, Jinan 250032, China;Class 1 of Grade 2013 of General Medicine, Binzhou Medical University, Shandong Province, Yantai 264003, China)

机构地区：[1]济南长峰血管瘤医院小儿血管瘤病区,250032 [2]山东国济血管瘤医院小儿病区,济南250032 [3]滨州医学院全科医学13级1班,山东省烟台264003

出　　处：《药物不良反应杂志》2018年第6期458-459,共2页Adverse Drug Reactions Journal

摘　　要：1例出生后70d女性患儿因血管瘤给予盐酸普萘洛尔口服。用药第5天患儿出现腹泻、便血,停用盐酸普萘洛尔并给予蒙脱石散(1.0g、3次/d)、双歧杆菌乳杆菌三联活菌片(0.5g、3次/d)口服,3d后症状消失,大便潜血试验阴性。1周后再次给予盐酸普萘洛尔口服,2d后患儿再次出现上述症状,停药后重复上次药物治疗方案并加用丁桂儿脐贴(1贴/d),治疗7d患儿症状无改善。经结肠镜检查和肠黏膜活检诊断为过敏性结肠炎。给予蒙脱石散(1.0g、3次/d)、双歧杆菌乳杆菌三联活菌片(0.5g、3次/d)和孟鲁司特钠片(1mg、1次/d)口服,游离氨基酸配方奶粉喂养。1周后,患儿腹泻、便血症状消失,大便潜血试验阴性。A 70-day-old female infant received propranolol hydrochloride orally for hemangioma.On day 5 after the medication,the infant developed diarrhea and hematochezia.Propranolol hydrochloride was discontinued,and montmorillonite powder 1.0 g and live combined Bifidobacterium,Lactobacillus and Streptococcus therophilus tablets 0.5 g were given thrice daily orally.Three days later,the symptoms disappeared and fecal occult blood test showed negative.One week later,propranolol hydrochloride was given again and,2 days later,the above symptoms recurred.Propranolol hydrochloride was stopped again and above therapeutic regime as well as Ding Guier umbilical paste was given(1 paste/d).The symptoms did not improve after 7 days of the treatment.The diagnosis of allergic colitis was confirmed through colonoscopy and intestinal mucosal biopy.Montmorillonite powder 1.0 g thrice daily,live combined Bifidobacterium,Lactobacillus and Streptococcus therophilus tablets 0.5 g thrice daily,and montelukast sodium tablets 1 mg once daily were given orally,and free amino acid-based infant formula was fed.A week later,the infant's diarrhea and hematocheiza disappeared and fecal occult blood test showed negative.

关 键 词：普萘洛尔 结肠炎 过敏反应 婴儿 

分 类 号：R725.7[医药卫生—儿科]