丁苯酞氯化钠注射液致肾损伤  

Kidney injury induced by butylphthalide and sodium chloride injection

作　　者：王带媚[1] 赵二义[2] 钟敬波[1] 韩方璇[1] 吕秀萍[1] Wang Daimei;Zhao Eryi;Zhong Jingbo;Hart Fangxuan;Lyu Xiuping(Department of Pharmacy, Hainan General Hospital, Haikou 570311, China;Department of Neurology, Hainan General Hospital, Haikou 570311, China)

机构地区：[1]海南省人民医院药学部,海口570311 [2]海南省人民医院神经内科,海口570311

出　　处：《药物不良反应杂志》2018年第6期463-464,共2页Adverse Drug Reactions Journal

摘　　要：1例58岁男性患者因急性缺血性脑卒中给予阿司匹林肠溶片200mg口服、1次/d,瑞舒伐他汀钙片10mg口服、1次/d,丁苯酞氯化钠注射液100ml(含丁苯酞25mg,氯化钠0.9g)静脉滴注、2次/d,曲克芦丁脑蛋白水解物10ml静脉滴注、1次/d。7d后实验室检查示血尿素6.9mmol/L,Scr131μmol/L,血胱抑素C1.54mg/L,考虑可能为丁苯酞氯化钠注射液所致肾损伤。停用该药,继续应用其他药物,并给予注射用血栓通和百令胶囊等药物治疗。6d后复查,血尿素6.2mmol/L,Scr104μmol/L,血胱抑素C1.05mg/L;2个月后复查,血尿素5.9mmol/L,Scr101μmol/L,血胱抑素C1.00mg/L。A 58-year-old male patient received aspirin enteric-coated tablets 200 mg and rosuvastatin calcium 10 mg once daily by mouth,IV infusions of butylphthalide and sodium chloride injection 100 ml(containing butylphthalide 25 mg and sodium chloride 0.9 g)twice daily and troxorutin brain protein hydrolysate 10 ml once daily for acute ischemic stroke.Seven days later,laboratory tests showed blood urea 6.9 mmol/L,serum creatinine(Scr)131 μmol/L,and blood cystatin C 1.54 mg/L.Kidney injury induced by butylphthalide and sodium chloride injection was considered.Butylphthalide and sodium chloride injection was stopped but the other drugs as well as Xueshuantong for injection(注射用血栓通)and Corbrin capsule(百令胶囊)were given.Laboratory tests showed blood urea 6.2 mmol/L,Scr 104 μmol/L,and blood cystatin C 1.05 mg/L 6 days later and then blood urea 5.9 mmol/L,Scr 101 μmol/L,and blood cystatin C 1.00 mg 2 months later.

关 键 词：卒中 急性肾损伤 丁苯酞氯化钠注射液 

分 类 号：R595.3[医药卫生—内科学]