神经节苷脂与醒脑静联合应用对急性脑卒中患者实验室指标及预后的影响  

Improvements of laboratory indicators and prognosis in patients with acute stroke treated with Ganglioside combined with Xingnaojing

作　　者：张冬惠[1] 徐莉娜[2] 王绍谦[1] 杨胜[1] 马汤力[1] 李莉娟[1] 金亚娟 ZHANG Dohghui;XU Lina;WANG Shaoqian;YANG Sheng;MA Tangli;LI Lijuan;JIN Yajuan(Emergency Department,The Second People's Hospital of Kaifeng City,Kaifeng 475002,China;Severe and Respiratory Department,The Second People's Hospital of Kaifeng City,Kaifeng 475002,China;Neurology Department,Yangling Demonstration Zone Hospital,Yangling 712100,China)

机构地区：[1]开封市第二人民医院急诊科,河南开封475002 [2]开封市第二人民医院重症与呼吸科,河南开封475002 [3]杨凌示范区医院神经内一科,陕西杨凌712100

出　　处：《药物评价研究》2018年第12期2277-2280,共4页Drug Evaluation Research

摘　　要：目的探讨神经节苷脂与醒脑静联合应用对急性脑卒中患者实验室指标及预后的影响。方法以开封市第二人民医院2013年9月—2017年6月130例急性脑卒中患者为研究对象,采用随机数字表法将入选者分为对照组和观察组,每组65例。对照组在常规治疗基础上将10～20 mL醒脑静注射液加入到0.9%的生理盐水250 mL中静脉滴注,1次/d。观察组在对照组的基础上将40 mg神经节苷脂钠注射液加入到0.9%的生理盐水250 mL中静脉滴注,1次/d。两组均治疗1个月。比较两组患者的临床疗效、治疗前后神经功能、认知功能、日常生活能力、血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平变化及不良反应发生情况。结果观察组及对照组患者治疗总有效率分别为90.77%、73.85%,观察组明显高于对照组,差异有统计学意义(P<0.05)。治疗前两组患者神经功能缺损程度(NIHSS)、简易智能状态检查量表(3MS)、巴氏指数(BI)评分及血清TNF-α、IL-6水平比较无显著性差异;治疗后两组患者NIHSS评分及血清TNF-α、IL-6水平均明显降低,3MS、BI评分明显升高,同组治疗前后比较存在显著性差异(P<0.05);治疗后观察组患者NIHSS、3MS、BI评分及及血清TNF-α、IL-6水平改善情况均显著优于对照组,两组比较存在显著性差异(P<0.05)。观察组及对照组患者各不良反应的发生率比较无显著性差异。结论神经节苷脂与醒脑静联合应用可有效改善患者的神经功能、认知功能及日常生活能力,提高治疗效果,降低血清炎性因子水平,且不增加不良反应,在急性脑卒中的治疗中具有重要应用价值。Objective To explore improvements of laboratory indicators and prognosis in patients with Acute stroke treated with ganglioside combined with xingnaojing.Methods 130 Patients with Acute stroke of The Second People's Hospital of Kaifeng City were selected as the subjects from September 2013 to June 2017.According to random number table method were divided into the control group and study group with 65 cases in each.The control group patients were treated with Xingnaojing,the experimental group on the basis of this combination of Ganglioside.Compared the two groups of patients with clinical effect,Neurological function,cognitive function,daily living ability(ADL),Serum TNF-α,IL-6 levels changing and incidence of adverse reactions before and after treatment.Results The total effective rate in the experimental group were obviously higher than those in the control group(P<0.05).Before treatment,there was no significant difference in NIHSS,3MS,BI score and serum TNF-α,IL-6 levels between the two groups.After treatment,NIHSS score and serum TNF-α,IL-6 levels were significantly decreased,while 3MS,BI scores were significantly increased,there were significant differences between before and after(P<0.05).The study group of NIHSS,3MS,BI scores and serum TNF-α,IL-6 levels were significantly better than that of the control group and there was significant difference(P<0.05).The incidence of adverse reactions had no statistically significant differences between the two groups.Conclusions Ganglioside combined with Xingnaojing in treating Acute stroke can effectively improve neurological function,cognitive function,daily living ability,enhance the therapeutic effect,reduce the level of serum inflammatory factors and don't increase the adverse reactions,which has important application value.

关 键 词：神经节苷脂 醒脑静 急性脑卒中 神经功能 炎症因子 不良反应 

分 类 号：R969[医药卫生—药理学]