丹参注射液联合小剂量阿司匹林治疗妊娠期高血压疾病的临床疗效及对患者血清相关指标的影响  

Clinical effect of Danshen injection combined with small-dosage aspirin in hypertensive disorder complicating pregnancy and the influence of serum related index

作　　者：樊阳阳 张京京 李秋敏[1] FAN Yangyang;ZHANG Jingjing;LI Qiumin(Maternity department,Shaanxi provincial people's hospital,Xi'an 710068,China)

机构地区：[1]陕西省人民医院产科,陕西西安710068

出　　处：《药物评价研究》2018年第12期2294-2298,共5页Drug Evaluation Research

摘　　要：目的分析丹参注射液联合小剂量阿司匹林治疗妊娠期高血压疾病的临床疗效及对患者血清相关指标的影响。方法以2013年1月—2016年8月陕西省人民医院收治的120例妊娠期高血压疾病患者为研究对象,根据随机数字表法分为观察组、对照1组和对照2组,每组40例。对照1组给予常规治疗,对照2组在常规治疗的基础上加用小剂量阿司匹林,观察组在对照2组治疗方法的基础上加用丹参注射液。比较3组治疗前后的血压、尿蛋白、临床疗效和血清炎症因子,包括肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、血清高迁移率蛋白-1(HMGB1)水平及母婴结局。结果治疗后,3组的收缩压、舒张压、24 h尿蛋白水平和孕妇血清中TNF-α、IL-6、HMGB1水平均较治疗前显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组的以上指标均显著低于对照1组和对照2组,差异有统计学意义(P<0.05);对照2组的亦显著低于对照1组,差异有统计学意义(P<0.05)。观察组和对照2组的临床治疗总有效率均显著高于对照1组,差异有统计学意义(P<0.05);观察组的临床治疗总有效率显著高于对照2组,差异有统计学意义(P<0.05)。观察组生产时胎龄显著高于对照1组和对照2组,差异有统计学意义(P<0.05);且对照2组生产时胎龄显著高于对照1组,差异有统计学意义(P<0.05)。3组剖宫产率、新生儿窒息率呈降低趋势,但两两比较,差异均无统计学意义。结论丹参注射液联合小剂量阿司匹林治疗妊娠期高血压疾病的临床疗效显著,可显著改善患者的临床症状、母婴结局,其作用机制可能与降低患者血清中TNF-α、IL-6、HMGB1水平有关。Objectove To investigate the clinical effect of danshen injection combined with small-dosage aspirin in hypertensive disorder complicating pregnancy(HDCP)and the influence of serum related index.Methods 120 cases of patients with HDCP in our hospital were selected and divided into observation group,control group-1and control group-2,40 cases in each group.Patients in the control group-1 were treated with regular treatment,and control group-2 were treated with regular treatment and small-dosage aspirin,observation group were treated with danshen injection based on the treatment method of control group-2.Compared the blood pressure,urinary protein and clinical curative effect,serum inflammatory cytokines(tumor necrosis factor-α(TNF-α),a interleukin 6(IL-6),serum high mobility protein 1(HMGB1)levels and and outcomes of three groups.Results After treatment,systolic pressure,diastolic pressure,24 h urine protein levels,pregnant women serum TNF-α,IL-6,HMGB1 levels in three group were significantly lower than before treatment(P<0.05),and the observation group were significantly lower than control group-1and control group-2(P<0.05),the control group-2 were also significantly lower than control group-1(P<0.05).The total effective rate,gestational week of observation group were significantly higher than control group-1and control group-2(P<0.05),the control group-2 were also significantly higher than control group-1(P<0.05).The gestational age of observation group were higher than group-1 and group-2(P<0.05).The Cesarean section rate,neonatal asphyxia rate of three groups were all decreased,which had no significant differences between two groups.Conclusion Danshen Injection combined with small-dosage aspirin has remarkable clinical effect in HDCP,can significantly improve the patient's clinical symptoms and outcomes,and its mechanism may be related to reduce patients' serum TNF-a,IL-6,HMGB1 levels.

关 键 词：妊娠期高血压疾病 丹参注射液 阿司匹林 血清指标 

分 类 号：R969[医药卫生—药理学]