强迫症患者内隐、外显记忆损伤特点与强迫症状的相关性研究  

Correlation between implicit and explicit memory impairment and clinical symptoms in patients with obsessive-compulsive disorder

作　　者：王小静 李晓驷[1,2] 钟慧[2] 靳胜春[2] 靳红[2] 王本红 吴小玲[1] Wang Xiaofing;Li Xiaosi;Zhong Hui;Jin Shengchun;Jin Hong;Wang Benhong;Wu Xiaoling(Department of Psychology of Anhui Medical University,Hefei 230032,China;Mental Health Clinical College of Anhui Medical University,Anhai Mental Health Center,Hefei 230032, China)

机构地区：[1]安徽医科大学医学心理学系,合肥230032 [2]安徽医科大学精神卫生临床学院,安徽省精神卫生中心,合肥230032

出　　处：《中华行为医学与脑科学杂志》2018年第12期1086-1090,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：合肥市卫生计生委应用医学研究项目(hwk2017yb017).

摘　　要：目的探讨强迫症(obsessive-compulsive disorder,OCD)患者内隐记忆与外显记忆的特点,及其与患者强迫症状的关系。方法纳入31例OCD患者(OCD组)和30名性别、年龄、受教育年限与患者相匹配的正常对照(正常对照组),以词汇知觉速度测验任务及词汇识别任务分别测试被试对中性词、积极情绪词、道德厌恶词的内隐记忆及外显记忆的反应时、正确率,采用帕多瓦量表-华盛顿州立大学修订版(Padua inventory-Washington State University revision,PI-WSUR)评估患者强迫症状。结果OCD组与正常对照组被试内隐记忆的反应时分别为[(2926.63±1718.31)ms]和[(2587.13±1054.56)ms],差异有统计学意义(t=0.926,P=0.358);两组被试内隐记忆中道德厌恶词的正确率分别为(0.607±0.267)和(0.777±0.159)(t=-3.036,P=0.004)、积极情绪词的正确率分别为(0.528±0.265)和(0.695±0.152)(t=-3.048,P=0.004)、三类词语总的正确率分别为(0.597±0.248)和(0.731±0.145)(t=-2.582,P=0.013),均差异有统计学意义(均P<0.05)。OCD组外显记忆的反应时与PI-WSUR总分(r=-0.410,P=0.022)、OTAHSO分(r=-0.470,P=0.008)呈负相关。结论OCD患者的内隐记忆受损,尤其是对积极情绪的词语和道德厌恶词语的内隐记忆较正常组差,OCD患者内隐记忆与症状无相关性;OCD患者的外显记忆与正常组比较无受损,OCD患者的外显记忆与强迫症症状有相关性。Objective To investigate the characteristics of implicit and explicit memory in patients with obsessive compulsive disorder(OCD)and its relationship with obsessive-compulsive symptoms.Methods Thirty-one patients with OCD and thirty healthy participants matched with sex,age,years of education were enrolled in present study.All participants were conducted vocabulary perception speed task and vocabulary recognition task to evaluate the ability of implicit memory and explicit memory toward neutral,positive and moral disgust words.The accuracy and response time during tasks were recorded to index memory performance.The obsessive-compulsive symptoms were assessed with Padovar scale-Washington State University revised edition(PI-WSUR).Results There was significant difference in the response time of implicit memory between two groups((2 926.63±1 718.31)ms for OCD group,(2 587.13±1 054.56)ms for controls group,t=0.926,P=0.358).There was significant difference two groups in the accuracy of implicit memory for moral disgust words((0.607±0.267)for OCD group,(0.777±0.159)for controls group,t=-3.306,P=0.004),positive words((0.528±0.265)for OCD group,(0.695±0.152)for controls group,t=-3.048,P=0.004)and all words((0.597±0.248)for OCD group,(0.731±0.145)for controls group,t=-2.582,P=0.013).The response time of explicit memory in OCD group was significantly correlated with PI-WSUR(r=-0.410,P=0.022),OTAHSO(r=-0.470,P=0.008).Conclusion Compared with healthy controls,the implicit memory of OCD patients was impaired,especially the implicit memory of positive emotion words and moral disgust words.There is no correlation between implicit memory and obsessive-compulsive symptoms in OCD patients.Compared with healthy controls,the implicit memory of OCD patients is not impaired,but there is a correlation between explicit memory and obsessive-compulsive symptoms in OCD patients.

关 键 词：强迫症 内隐记忆 外显记忆 相关性 

分 类 号：R749.7[医药卫生—神经病学与精神病学]