苄星青霉素与头孢三嗪不同用药方案对患者早期梅毒的临床疗效及其对梅毒血清学转阴的影响  

Clinical Efficacy of Different Regimens of Benzathine Penicillin and Ceftriazine in Patient with Early Syphilis and Influence on Conversion of RPR

作　　者：李舒[1] LI Shu(Dermatology,The No.7 People's Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]郑州市第七人民医院皮肤科,郑州450000

出　　处：《抗感染药学》2018年第11期1945-1947,共3页Anti-infection Pharmacy

摘　　要：目的:探究苄星青霉素与头孢三嗪不同用药方案对患者早期梅毒的临床疗效及其对梅毒血清学转阴的影响。方法:选取近年医院收治的早期梅毒患者156例资料,将其随机分为A、B、C组,每组52例;其中A组患者给予苄星青霉素治疗,B组患者给予头孢三嗪治疗,C组患者给予苄星青霉素与头孢三嗪联用治疗,比较3组患者治疗后的总有效率和随访12月的梅毒血清学试验(RPR)转阴率的差异。结果:C组患者临床治疗后的总有效率为92.31%分别高于A组为76.92%和B组为75.00%(P<0.05);随访12月,C组患者RPR试验呈阴性率为86.54%分别高于A组为73.08%和B组为69.23%(P<0.05)。结论:苄星青霉素与头孢三嗪联用治疗早期梅毒患者的临床疗效更为确切,有效提高了RPR转阴率。Objective: To study the clinical efficacy of different regimens of benzathine penicillin and ceft-riazine in patient with early syphilis and their influence on conversion of syphilis serological test(RPR). Methods: A total of 156 patients with early syphilis admitted to our hospital in recent years were randomly divided into A, B, and C groups;52 of them were treated with benzathine penicillin, group B with ceftriaxone, and group C with benzathine penicillin combined with cephalosporin, triazine treatment;the clinical efficacy of the three groups was compered, followed up for 12 months, comparing with the syphilis serological test(RPR) conversion rate. Results: The total clinical effective rate of group C was 92.31%, which was higher than 76.92% in group A and 75.00% in group B(P<0.05). After 12 months of follow-up, the negative rate of RPR in group C was 86.54%, which was higher than 73.08% in group A and 69.23%in group B(P<0.05). Conclusion: The clinical efficacy of benzathine penicillin combined with ceftriazine in the treatment of early syphilis patients was more accurate, and the RPR conversion rate was effectively improved.

关 键 词：苄星青霉素 头孢三嗪 不同用药方案 早期梅毒 梅毒血清学 临床疗效 

分 类 号：R969.3[医药卫生—药理学]