缩宫素联合欣母沛对疤痕子宫二次剖宫产术后止血和凝血功能影响研究  

Study on effect of oxytocin combined with Xinmupei on hemostasis and coagulation function of scarred uterus after second cesarean section

作　　者：周少臣 安洪宾 ZHOU Shao-chen;AN Hong-bin(Department of Obstetrics and Gynecology,Faku County Central Hospital,Shenyang 110499,China)

机构地区：[1]法库县中心医院妇产科,110499

出　　处：《中国实用医药》2019年第2期18-19,共2页China Practical Medicine

摘　　要：目的研究缩宫素联合卡前列素氨丁三醇注射液(欣母沛)对疤痕子宫二次剖宫产术后止血和凝血功能的影响。方法 90例疤痕子宫二次剖宫产患者,按照随机数字表法分为对照组和观察组,每组45例。对照组患者给予缩宫素进行注射治疗,观察组患者在对照组基础上联合欣母沛进行注射治疗。比较两组患者的术中、产后2 h、产后24 h出血量,止血和凝血时间及产后不良反应发生情况。结果治疗后,观察组患者术中、术后2 h、术后24 h出血量分别为(213.46±45.07)、(297.64±51.23)、(302.29±40.21)ml,均明显少于对照组的(335.84±60.25)、(426.57±73.48)、(514.82±86.16)ml,差异均有统计学意义(t=10.9108、11.0034、14.9945, P<0.05)。观察组术后止血时间和凝血时间分别为(31.22±4.17)、(29.65±3.14)h,均明显短于对照组的(48.62±8.03)、(40.58±6.43)h,差异均有统计学意义(t=12.9001、10.2464, P<0.05)。观察组患者产后不良反应发生率为6.67%,明显低于对照组的24.44%,差异有统计学意义(χ~2=5.4135, P=0.0200<0.05)。结论缩宫素联合欣母沛治疗疤痕子宫二次剖宫产术后出血的效果显著,能够减少术中及产后出血量,降低术后不良反应发生率,安全性较高,值得在临床推广。Objective To study the effect of oxytocin combined with carboprost tromethamine injection(Xinmupei) on hemostasis and coagulation function of scarred uterus after second cesarean section. Methods A total of 90 scarred uterus patients with second cesarean section were divided by random number table method into control group and observation group, with 45 cases in each group. The control group received oxytocin for injection treatment, and the observation group received Xinmupei for injection treatment on the basis of the control group. Comparison were made on bleeding volume during the operation, 2 h and 24 h after postpartum, hemostasis and clotting time and occurrence of postpartum adverse reactions between the two groups. Results After treatment, the observation group had bleeding volume during the operation, 2 h and 24 h after postpartum respectively as(213.46±45.07),(297.64±51.23) and(302.29±40.21) ml, which were all obviously less than(335.84±60.25),(426.57±73.48) and(514.82±86.16) ml in the control group, and their difference was statistically significant(t=10.9108, 11.0034, 14.9945, P<0.05). The observation group had obviously shorter postoperative hemostasis time and clotting time respectively as(31.22±4.17),(29.65±3.14) h than(48.62±8.03) and(40.58±6.43) h in the control group, and their difference was statistically significant(t=12.9001, 10.2464, P<0.05). The observation group had obviously lower incidence of postpartum adverse reactions as 6.67% than 24.44% in the control group, and the difference was statistically significant(χ^2=5.4135, P=0.0200<0.05). Conclusion Combination of oxytocin and Xinmupei shows remarkable effect in treating secondary cesarean section of scarred uterus, and it can reduce the amount of intraoperative and postpartum hemorrhage, reduce the incidence of postoperative adverse reactions with high safety. It is worthy of clinical promotion.

关 键 词：缩宫素 卡前列素氨丁三醇注射液 疤痕子宫二次剖宫产 止血和凝血功能 

分 类 号：R719.8[医药卫生—妇产科学]