补骨脂化学成分及药理作用研究进展  

Research Progress on Chemical Constituents and Pharmacological Actions of Psoralea Fructus

作　　者：鲁亚奇 张晓 王金金[1] 李凯[1,2] 周宁 张振凌[1,2] LU Ya-qi;ZHANG Xiao;WANG Jin-jin;LI Kai;ZHOU Ning;ZHANG Zhen-ling(Henan University of Chinese Medicine,Zhengzhou 450046,China;Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学,郑州450046 [2]呼吸疾病诊疗与新药研发河南省协同创新中心,郑州450046

出　　处：《中国实验方剂学杂志》2019年第3期180-189,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81403102);河南省高等学校重点科研项目(19A360001)

摘　　要：补骨脂是临床常用中药,其性温,味辛、苦,归肾、脾经,具有温肾助阳、纳气平喘、温脾止泻的作用,外用消风祛斑。近些年来,补骨脂的化学及药理作用研究取得长足进展,学者已从中分离出近百种香豆素类、黄酮类、单萜酚类化合物,也发现其中含类脂类、糖苷类、挥发油以及微量元素等多种类型的化合物。该文通过查阅原始文献,总结了主要化合物类型及化学分子式,详细综述了其在抗肿瘤、抗氧化、抗菌、抗炎、抗抑郁、调节雌激素水平、促进骨生长、神经保护及对肝脏的影响等方面的药理作用,并将具有相同或相似药理作用的化合物分类总结,以寻找补骨脂中化学成分与其药理作用之间的关系。补骨脂及以其开发的现代制剂在现代临床中应用较为广泛,该文通过查阅国内外补骨脂中化学成分研究文献及其近些年的药理活性研究文献,系统整理、分析、总结了其化学成分和药理活性的研究进展,更正了个别化合物的化学类型,以期为补骨脂药效物质基础、质量标准及药理活性的深入研究提供参考。Psoralea Fructus,a commonly used traditional Chinese medicine in clinical application,is warm,spicy and bitter in nature and belongs to the kidney and spleen meridian. Psoralea Fructus has the function of warming kidney and tonifying yang,absorbing Qi and relieving asthma,warming spleen and stopping diarrhea,and in topical use,it can remove beverage. In recent years,considerable progress has been made in the study of chemical constituents and pharmacological effects of Psoralea Fructus. Nearly one hundred compounds have been isolated from it,including coumarins,flavonoids,and meroterpenes,and various types of compounds such as lipids,glycosides,volatile oils,and trace elements have been also found in Psoralea Fructus. In this article,the original literature was reviewed to summarize the main compound types and structural formula,with detailed reviews on pharmacological studies about its anti-tumor,anti-oxidant,anti-bacterial,anti-inflammatory,anti-depressive,regulating estrogen level,promoting bone growth,liver protection,and neuroprotection effects. In addition,the compounds with the same or similar pharmacological effects were sorted out and summarized to correlate the chemical structure and pharmacology. Psoralea Fructus and its modern preparations are widely used in modern clinical practice. The researches and papers on chemical constituents of Psoralea Fructus at home and abroad and the papers on pharmacological activities in recent years were reviewed, and the chemical types of individual compounds were corrected in this article,providing a reference for further study of Psoralea Fructus in efficacy material basis,quality standards and pharmacological activities.

关 键 词：补骨脂 化学成分 药理作用 香豆素 黄酮 单萜酚 

分 类 号：R284.1[医药卫生—中药学] R289[医药卫生—中医学]