氮氧自由基TEMPO在合成化学中的应用进展  

Progress on Application of Nitroxide Radical TEMPO in Synthetic Chemistry

作　　者：常盛 杨述祯 岳慧娟 杨丰科[1] CHANG Sheng;YANG Shu-zhen;YUE Hui-juan;YANG Feng-ke(Department of Chemical Engineering,Qingdao University of Science and Technology,Qindao 266000, China)

机构地区：[1]青岛科技大学化工学院,山东青岛266000

出　　处：《化学试剂》2019年第1期23-29,共7页Chemical Reagents

摘　　要：氧化反应及硝化反应是化学合成中的基础反应类型,传统合成方法污染性大且选择性差,绿色环保的实验方法更加受到青睐。2,2,6,6-四甲基哌啶-1-氧自由基(TEMPO)是一种稳定的自由基,自发现以来被广泛地应用在化学合成的各个领域中。因其具有高活性、高选择性和高稳定性,因此在醇的氧化反应和烯烃的硝化反应上得到广泛应用。以TEMPO在醇氧化反应及烯烃的硝化反应上的应用为方向,描述了TEMPO在各种不同助氧化剂及硝化剂下参与的氧化反应及硝化反应,并综述了最新的研究进展。Oxidation and nitration are the primary reactions types in chemical synthesis,but the traditional methods have the disadvantages of severe pollution and poor selectivity.The green environmental experiment method is more favored.2,2,6,6-tetramethylpiperidine-1-oxyl radical( TEMPO) as green and stable free radical,has been widely used in various fields of chemical synthesis.It has been employed in the oxidation of alcohols and high stability.Based on the application of TEMPO in alcohol oxidation and olefin nitration,the latest research progress with regards to the oxidation and nitration reactions of TEMPO under the presence of varying oxidants and nitrating agents was reviewed.

关 键 词：TEMPO 催化剂 氧化反应 硝化反应 

分 类 号：O621.2[理学—有机化学]