稳定同位素标记卤代苯-D_5的合成  

Syntheses of Stable Isotope Labelled Halogenated Benzene-D_5

作　　者：杨超 杨维成 潘洁 YANG Chao;YANG Wei-cheng;PAN Jie(Shanghai Research Institute of Chemical Industry Co.,Ltd.,Shanghai 200062,China;Shanghai Engineering Research Center of Stable Isotope,Shanghai 200062,China)

机构地区：[1]上海化工研究院有限公司,上海200062 [2]国家同位素工程技术研究中心-上海分中心,上海200062

出　　处：《化学试剂》2019年第1期89-92,共4页Chemical Reagents

基　　金：上海市科技创新行动计划项目(17142201400)

摘　　要：以同位素标记苯-D6为起始原料,经卤代反应得到标题化合物。以消耗的苯-D6计算,稳定同位素标记氯苯-D5、溴苯-D5、碘苯-D5的收率分别为80. 3%、82. 1%、84. 3%,产品结构经气相色谱(GC)、气质联用(GC-MS)及核磁(13CNMR)等仪器表征确定,色谱纯度高于99. 0%,同位素丰度>99. 0%atom D,可作为稳定同位素标记化合物合成的基础试剂使用。An efficient synthesis of the title compounds with benzene-D6 as the precursor by halogenation was presented.The yields of chlorobenzene-D5,bromobenzene-D5,iodobenzene-D5 were 80. 3%,82. 1%,84. 3%,based on benzene-D6 consumed.The products were confirmed by GC,GC-MS,and13 CNMR. The chemical purities and isotopic enrichment are higher than 99. 0%. The above compounds could be used as basic reagent for stable isotope labeling compounds synthesis.

关 键 词：同位素标记 氯苯 溴苯 碘苯 中间体 

分 类 号：TQ421.6[化学工程]