2-脱氧-D-葡萄糖的合成研究  

Synthesis of 2-Deoxy-D-glucose

作　　者：孙昊[1] 刘鹏[1] 袁文蛟[1] SUN Hao;LIU Peng;YUAN Wen-jiao(Tianjin Modern Vocational Technology College,Tianjin 300350,China)

机构地区：[1]天津现代职业技术学院,天津300350

出　　处：《化学试剂》2019年第1期99-101,共3页Chemical Reagents

基　　金：天津市津南区科技计划项目(20171509);天津市科技计划项目(16YFFCZC00070);河北省科技计划项目(15211232)

摘　　要：标题化合物具有多种生物活性,被广泛地应用在药品和食品领域。在研究活化二甲基亚砜(DMSO)时,偶然发现在碘化钾(KI)存在下氯甲基甲硫醚(CH3SCH2Cl)具有温和的路易斯酸性。因此,利用KI/CH3SCH2Cl体系,以3,4,6-O-三乙酰基-D-葡萄糖糖烯为起始原料,经催化水合和脱保护两步反应,便可高效制得标题化合物(异构体比例为1∶2),总收率77. 6%。该方法反应条件温和、反应收率较高,具有良好的工业应用前景。Due to various bioactivities,The target compound is widely used in the field of medicine and food.It was discovered that CH3 SCH2 Cl demonstrated Lewis acidity in the presence of KI,when active DMSO was investigated.3,4,6-tri-O-acetyl-D-glucal was transformed into the target compound( α ∶β = 1 ∶2) via hydration reaction mediated by KI/CH3 SCH2 Cl and de-protection reaction with the 77. 6% yield in total.These reaction conditions are mild and reaction yields are high,which shows potential in the industrial application.

关 键 词：2-脱氧-D-葡萄糖 CH3SCH2Cl 水合反应 葡萄糖糖稀 

分 类 号：TQ463[化学工程—制药化工]