论共生系统:肠道菌群和人类健康  

On the Symbiotic System:Gut Microbiota and Human Health

作　　者：吴泽昂[1] 王晓丽[1] 王海霞[2] WU Zeang;WANG Xiaoli;WANG Haixia(Shihezi University First Affiliated Hospital,Xinjiang Shihezi 832002,China;Shihezi University School of Medicine,Xinjiang Shihezi 832002,China)

机构地区：[1]石河子大学医学院第一附属医院,新疆石河子832002 [2]石河子大学医学院,新疆石河子832002

出　　处：《河南大学学报（自然科学版）》2019年第1期36-47,共12页Journal of Henan University:Natural Science

基　　金：国家自然科学基金资助项目(81660149)

摘　　要：共生是生物界中普遍存在的一种现象,互利共生的一个典型例子就是人类和肠道菌群.人类利用肠道菌群消化食物来获得生存所需的能量和营养,而肠道菌群则获得栖息地和营养.肠道菌群与人类相互作用形成了一种与人类健康密切相关的平衡状态,打破这种平衡状态会导致人体内的许多疾病,如肥胖、高血压、炎症性肠病、癌症等.肠道菌群参与宿主新陈代谢、机体免疫、基因表达、疾病发展和药物疗效,同时它也受饮食、抗生素、生活方式、遗传和时间点的影响.作者系统地回顾了人类与肠道菌群之间的相互作用,分析了肠道菌群在人类疾病治疗中的应用现状,描述了治疗中存在的主要问题,为肠道菌群在人类疾病治疗中的应用提供了新的思路.Symbiosis is a ubiquitous phenomenon in the biological world.A typical example of mutualism is human and gut microbiota.Humans use the gut microbiota to consume food to get the energy and nutrients necessary for survival,while the gut microbiota gains habitat and nutritions.Gut microbiota interacts with humans to form a balance state that is closely related to human health,and the disequilibrium can result in many diseases in human such as obesity,high blood pressure,inflammatory bowel disease,cancer and so on.The gut microbiota participates in host metabolism,organism immunity,gene expression,disease development and drug efficacy,while it is also affected by diet,antibiotics,lifestyle,inheritance and time.The authors systernatically reviewed the interaction between human and gut microbiota,analyzed the application status of the gut microbiota in the treatment of human diseases,described the main problems in the treatment and provided new ideas for the application of gut microbiota in the treatment of human diseases.

关 键 词：肠道菌群 共生 人类健康 疾病治疗 

分 类 号：Q938.1[生物学—微生物学]